Mps1-IN-3( —— )

Catalog No. M23708 CAS No. 1609584-72-6

Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

Mps1-IN-3
Note

Research use only, not for human use.
Brief Description

Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).
Description

Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).
In Vitro

Mps1-IN-3 is a potent MPS1 kinase inhibitor, with an IC50 of 50 nM. Mps1-IN-3 inhibits the proliferation of U251 glioblastoma cells with an IC50 of appr 5 μM. Mps1-IN-3 (2 μM) can completely abrogates checkpoint.
In Vivo

Mps1-IN-3 (2 mg/kg, i.v.) sensitizes glioblastoma cells in murine tumor models, with prolonged survival and no toxicity.
Synonyms

——
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Kinesin
Recptor

Mps1
Research Area

——
Indication

——

Chemical Information

CAS Number

1609584-72-6
Formula Weight

537.63
Molecular Formula

C26H31N7O4S
Purity

>98% (HPLC)
Solubility

DMSO:5 mM
SMILES

O=S(C1=C(NC2=NC(NC3=CC=C(N4CCC(O)CC4)C=C3OC)=NC5=C2N=CN5)C=CC=C1)(C(C)C)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Tannous BA, et al. Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs. J Natl Cancer Inst. 2013 Sep 4;105(17):1322-31.

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