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Home - Products - Chromatin/Epigenetic - Epigenetic Reader Domain - MS645

MS645

CAS No. 2250091-96-2

MS645( —— )

Catalog No. M26309 CAS No. 2250091-96-2

MS645 is an inhibitor of bromodomain-containing protein 4 (BRD4) with a Ki of 18.4 nM for BRD4-BD1/BD2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MS645
  • Note
    Research use only, not for human use.
  • Brief Description
    MS645 is an inhibitor of bromodomain-containing protein 4 (BRD4) with a Ki of 18.4 nM for BRD4-BD1/BD2.
  • Description
    MS645 is an inhibitor of bromodomain-containing protein 4 (BRD4) with a Ki of 18.4 nM for BRD4-BD1/BD2.(In Vitro):MS645 blocks the proliferation of triple-negative breast cancer (TNBC) cells.?MS645 down-regulates proinflammatory cytokines and genes for cell-cycle control and DNA damage repair that are largely unaffected by monovalent BRD inhibition.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    Androgen Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2250091-96-2
  • Formula Weight
    938.05
  • Molecular Formula
    C48H54Cl2N10O2S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 200 mg/mL (213.21 mM)
  • SMILES
    Cc1nnc2[C@H](CC(=O)NCCCCCCCCCCNC(=O)C[C@@H]3N=C(c4c(C)c(C)sc4-n4c(C)nnc34)c3ccc(Cl)cc3)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Murakoshi M, et al. Discovery and pharmacological effects of a novel GPR142 antagonist. J Recept Signal Transduct Res. 2017;37(3):290-296.
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