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Alobresib

CAS No. 1637771-14-2

Alobresib ( Vorolanib,GS-5829 )

Catalog No. M21949 CAS No. 1637771-14-2

Alobresib is an inhibitor of BET bromodomain,is an antineoplastic drug candidate.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Alobresib
  • Note
    Research use only, not for human use.
  • Brief Description
    Alobresib is an inhibitor of BET bromodomain,is an antineoplastic drug candidate.
  • Description
    Alobresib is an inhibitor of BET bromodomain,is an antineoplastic drug candidate.in vitro experiments demonstrated high sensitivity of USC cell lines to the exposure to GS-5829, GS-626510, and JQ1 with BET inhibitors causing a dose-dependent decrease in the phosphorylated levels of c-Myc and a dose-dependent increase in caspase activation (apoptosis).?In comparative in vivo experiments, GS-5829 and/or GS-626510 were found more effective than JQ1 at the concentrations/doses used in decreasing tumor growth in both USC-ARK1 and USC-ARK2 mouse xenograft models.
  • Synonyms
    Vorolanib,GS-5829
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    BET
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    1637771-14-2
  • Formula Weight
    437.5
  • Molecular Formula
    C26H23N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ccccn1)c1ccccn1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bonazzoli E, et al. Inhibition of BET Bromodomain Proteins with GS-5829 and GS-626510 in Uterine Serous Carcinoma, a Biologically Aggressive Variant of Endometrial Cancer. Clin Cancer Res. 2018 Oct 1;24(19):4845-4853.
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