OTX015 ( HY-15743; ()-OTX015 )

Catalog No. M13154 CAS No. 202590-98-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

OTX015
Note

Research use only, not for human use.
Brief Description

OTX015 is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4. Phase 1.
Description

OTX015 is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4. Phase 1.
Synonyms

HY-15743; ()-OTX015
Pathway

Chromatin/Epigenetic
Target

Epigenetic Reader Domain
Recptor

BRDs
Research Area

Cancer
Indication

——

CAS Number

202590-98-5
Formula Weight

491.99
Molecular Formula

C25H22ClN5O2S
Purity

>98%(HPLC)
Solubility

DMSO:98 mg/mL (199.19 mM); Ethanol:98 mg/mL (199.19 mM); Water:<1 mg/mL (<1 mM)
SMILES

O=C(NC1=CC=C(O)C=C1)C[C@H]2C3=NN=C(C)N3C4=C(C(C)=C(C)S4)C(C5=CC=C(Cl)C=C5)=N2
Chemical Name

(S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetamide.

1.Noel JK, et al. Mol Cancer Ther. 2013, 12, C244.

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