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LY-411575
CAS No. 209984-57-6
LY-411575 ( LY411575;LY 411575 )
Catalog No. M13327 CAS No. 209984-57-6
A potent γ-secretase inhibitor that has an IC50 value of 119 pM for reduction of Aβ levels in APP-transfected cell lines.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 34 | In Stock |
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| 5MG | 55 | In Stock |
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| 10MG | 96 | In Stock |
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| 25MG | 200 | In Stock |
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| 50MG | 389 | In Stock |
|
| 100MG | 575 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLY-411575
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NoteResearch use only, not for human use.
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Brief DescriptionA potent γ-secretase inhibitor that has an IC50 value of 119 pM for reduction of Aβ levels in APP-transfected cell lines.
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DescriptionA potent γ-secretase inhibitor that has an IC50 value of 119 pM for reduction of Aβ levels in APP-transfected cell lines; dose dependently reduces Aβ(1-40) and Aβ(1-42) in the brain, CSF, and plasma of Tg2576 mice; reduces cortical Abeta(40) in young transgenic CRND8 mice with ED50 of 0.6 mg/kg, and produces significant thymus atrophy and intestinal goblet cell hyperplasia at higher doses (>3 mg/kg).Alzheimer's Disease Preclinical
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SynonymsLY411575;LY 411575
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PathwayWnt/Notch/Hedgehog
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Targetγ-secretase
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RecptorNotchS3cleavage;γsecretase(cell-based);γsecretase(membrane-based)
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Research AreaNeurological Disease
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IndicationAlzheimer Disease
Chemical Information
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CAS Number209984-57-6
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Formula Weight479.48
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Molecular FormulaC26H23F2N3O4
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC[C@@H](C(N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C)C1=O)=O)NC([C@H](C4=CC(F)=CC(F)=C4)O)=O
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Chemical NameBenzeneacetamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-.alpha.-hydroxy-, (.alpha.S)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lanz TA, et al. J Pharmacol Exp Ther. 2004 Apr;309(1):49-55.
2. Best JD, et al. J Pharmacol Exp Ther. 2005 May;313(2):902-8.
3. Hyde LA, et al. J Pharmacol Exp Ther. 2006 Dec;319(3):1133-43.
2. Best JD, et al. J Pharmacol Exp Ther. 2005 May;313(2):902-8.
3. Hyde LA, et al. J Pharmacol Exp Ther. 2006 Dec;319(3):1133-43.
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