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Home - Products - Membrane Transporter/Ion Channel - AMPK - MK-8722

MK-8722

CAS No. 1394371-71-1

MK-8722 ( —— )

Catalog No. M11645 CAS No. 1394371-71-1

A potent, selective, allosteric pan-AMPK activator with EC50 of 1-60 nM for all 12 mammalian AMPK isoforms.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MK-8722
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, allosteric pan-AMPK activator with EC50 of 1-60 nM for all 12 mammalian AMPK isoforms.
  • Description
    A potent, selective, allosteric pan-AMPK activator with EC50 of 1-60 nM for all 12 mammalian AMPK isoforms; exhibits higher affinity for β1-containing (1-6 nM) versus β2-containing (15-63 nM) pAMPK complexes; increases glucose uptake into skeletal muscle in vitro and in vivo, but induces cardiac hypertrophy.Diabetes Preclinical
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    AMPK
  • Recptor
    AMPK
  • Research Area
    Metabolic Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    1394371-71-1
  • Formula Weight
    449.89
  • Molecular Formula
    C24H20ClN3O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 62.5 mg/mL 138.92 mM
  • SMILES
    ClC1=C2C(NC(O[C@@H]3CO[C@@]4([H])[C@]3([H])OC[C@H]4O)=N2)=NC=C1C5=CC=C(C6=CC=CC=C6)C=C5
  • Chemical Name
    (3R,3aR,6R,6aR)-6-((6-([1,1'-biphenyl]-4-yl)-7-chloro-3H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Myers RW, et al. Science. 2017 Aug 4;357(6350):507-511.
2. Danqing Feng, et al. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.7b00417
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