MK-8722 ( —— )

Catalog No. M11645 CAS No. 1394371-71-1

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Product Name

MK-8722
Note

Research use only, not for human use.
Brief Description

A potent, selective, allosteric pan-AMPK activator with EC50 of 1-60 nM for all 12 mammalian AMPK isoforms.
Description

A potent, selective, allosteric pan-AMPK activator with EC50 of 1-60 nM for all 12 mammalian AMPK isoforms; exhibits higher affinity for β1-containing (1-6 nM) versus β2-containing (15-63 nM) pAMPK complexes; increases glucose uptake into skeletal muscle in vitro and in vivo, but induces cardiac hypertrophy.Diabetes Preclinical
Synonyms

——
Pathway

Membrane Transporter/Ion Channel
Target

AMPK
Recptor

AMPK
Research Area

Metabolic Disease
Indication

——

CAS Number

1394371-71-1
Formula Weight

449.89
Molecular Formula

C24H20ClN3O4
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 62.5 mg/mL 138.92 mM
SMILES

ClC1=C2C(NC(O[C@@H]3CO[C@@]4([H])[C@]3([H])OC[C@H]4O)=N2)=NC=C1C5=CC=C(C6=CC=CC=C6)C=C5
Chemical Name

(3R,3aR,6R,6aR)-6-((6-([1,1'-biphenyl]-4-yl)-7-chloro-3H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol

1. Myers RW, et al. Science. 2017 Aug 4;357(6350):507-511.
2. Danqing Feng, et al. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.7b00417

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