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MK-8722
CAS No. 1394371-71-1
MK-8722( —— )
Catalog No. M11645 CAS No. 1394371-71-1
A potent, selective, allosteric pan-AMPK activator with EC50 of 1-60 nM for all 12 mammalian AMPK isoforms.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 40 | Get Quote |
|
| 5MG | 65 | Get Quote |
|
| 10MG | 110 | Get Quote |
|
| 25MG | 214 | Get Quote |
|
| 50MG | 397 | Get Quote |
|
| 100MG | 584 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMK-8722
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, allosteric pan-AMPK activator with EC50 of 1-60 nM for all 12 mammalian AMPK isoforms.
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DescriptionA potent, selective, allosteric pan-AMPK activator with EC50 of 1-60 nM for all 12 mammalian AMPK isoforms; exhibits higher affinity for β1-containing (1-6 nM) versus β2-containing.(15-63 nM) pAMPK complexes; increases glucose uptake into skeletal muscle in vitro and in vivo, but induces cardiac hypertrophy.Diabetes Preclinical
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetAMPK
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RecptorAMPK
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Research AreaMetabolic Disease
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Indication——
Chemical Information
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CAS Number1394371-71-1
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Formula Weight449.891
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Molecular FormulaC24H20ClN3O4
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 62.5 mg/mL 138.92 mM
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SMILESClC1=C2C(NC(O[C@@H]3CO[C@@]4([H])[C@]3([H])OC[C@H]4O)=N2)=NC=C1C5=CC=C(C6=CC=CC=C6)C=C5
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Chemical Name(3R,3aR,6R,6aR)-6-((6-([1,1'-biphenyl]-4-yl)-7-chloro-3H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Myers RW, et al. Science. 2017 Aug 4;357(6350):507-511.
2. Danqing Feng, et al. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.7b00417
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