MT47-100

Research use only, not for human use.

A novel potent, allosteric, simultaneously direct activator and inhibitor of AMPK complexes containing the β1 or β2 isoform, respectively.

A novel potent, allosteric, simultaneously direct activator and inhibitor of AMPK complexes containing the β1 or β2 isoform, respectively; maximally activates α1β1γ1 approximately 2.5-fold with half-maximal activation Ka of 3.7 uM and activates all AMPKβ1 complexes regardless α or γ isoforms; directly inhibits AMPKβ2 complexes independently of α or γ isoforms with Ki of 24.8 uM, this inhibition is dependent on the β2 carbohydrate-binding module (CBM) and independent of β2-Ser108 phosphorylation; augmentes glucose-stimulated insulin secretion from isolated mouse pancreatic islets via a β2-dependent mechanism.

MT 47-100

Membrane Transporter/Ion Channel

AMPK

AMPK

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1179347-23-9

354.37

C22H14N2O3

>98% (HPLC)

——

C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CC4=C(C=C3)NC(=O)C(=C4O)C#N)O

2,4-dihydroxy-6-(2'-hydroxy-[1,1'-biphenyl]-4-yl)quinoline-3-carbonitrile

(-20℃)

With Ice Pack

≥ 2 years