Ampkinone ( —— )

Catalog No. M10921 CAS No. 1233082-79-5

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HNMR

HPLC

MSDS

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Product Name

Ampkinone
Note

Research use only, not for human use.
Brief Description

Ampkinone is a novel small molecule activator of AMPK, stimulates the phosphorylation of AMPK via indirect activation of AMPK in various cell lines.
Description

Ampkinone is a novel small molecule activator of AMPK, stimulates the phosphorylation of AMPK via indirect activation of AMPK in various cell lines (2.7-fold at 10 uM); Ampkinone-mediated activation of AMPK requires the activity of LKB1 and results in increased glucose uptake in muscle cells; significantly reduces total body weight and overall fat mass in DIO mice, effectively improves metabolic abnormalities in the DIO mice model.
Synonyms

——
Pathway

Membrane Transporter/Ion Channel
Target

AMPK
Recptor

AMPK
Research Area

Metabolic Disease
Indication

——

CAS Number

1233082-79-5
Formula Weight

505.52
Molecular Formula

C31H23NO6
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CC1(C2=C(C=CC3=C2C(=O)N(C3=O)C4=CC=C(C=C4)C(=O)C5=CC=CC=C5)C6=C(O1)C(=C(C=C6)OC)O)C
Chemical Name

[1]Benzopyrano[3,4-e]isoindole-1,3(2H,4H)-dione, 2-(4-benzoylphenyl)-6-hydroxy-7-methoxy-4,4-dimethyl-

1. Oh S, et al. J Med Chem. 2010 Oct 28;53(20):7405-13.

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