MK-0752 ( MK0752;MK 0752 )

Catalog No. M14568 CAS No. 471905-41-6

A potent γ-secretase inhibitor that shows dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

MK-0752
Note

Research use only, not for human use.
Brief Description

A potent γ-secretase inhibitor that shows dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells.
Description

A potent γ-secretase inhibitor that shows dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells; Notch signaling inhibitor.Breast Cancer Phase 2 Clinical
Synonyms

MK0752;MK 0752
Pathway

Wnt/Notch/Hedgehog
Target

γ-secretase
Recptor

Aβ
Research Area

Cancer
Indication

Breast Cancer

Chemical Information

CAS Number

471905-41-6
Formula Weight

442.90
Molecular Formula

C21H21ClF2O4S
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C(O)CC[C@H]1CC[C@](C2=CC(F)=CC=C2F)(S(=O)(C3=CC=C(Cl)C=C3)=O)CC1
Chemical Name

Cyclohexanepropanoic acid, 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-, cis-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Cook JJ, et al. J Neurosci. 2010 May 12;30(19):6743-50.
2. Previs RA, et al. Clin Cancer Res. 2015 Mar 1;21(5):955-61.
3. Brana I, et al. Br J Cancer. 2014 Nov 11;111(10):1932-44.

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