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MK-0752

CAS No. 471905-41-6

MK-0752( MK0752 | MK 0752 )

Catalog No. M14568 CAS No. 471905-41-6

A potent γ-secretase inhibitor that shows dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MK-0752
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent γ-secretase inhibitor that shows dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells.
  • Description
    A potent γ-secretase inhibitor that shows dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells; Notch signaling inhibitor.Breast Cancer Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male rhesus monkeysDosage:60-240 mg/kg Administration:P.o.Result:Generation of new Aβ was partially blocked with administration of 60 mg/kg, and nearly completely blocked at the 240 mg/kg dose as indicated by the dose-dependent decrease in the amount of 13C6-leucine-labeled Aβ.
  • Synonyms
    MK0752 | MK 0752
  • Pathway
    Wnt/Notch/Hedgehog
  • Target
    γ-secretase
  • Recptor
    Aβ
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    471905-41-6
  • Formula Weight
    442.9038
  • Molecular Formula
    C21H21ClF2O4S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(O)CC[C@H]1CC[C@](C2=CC(F)=CC=C2F)(S(=O)(C3=CC=C(Cl)C=C3)=O)CC1
  • Chemical Name
    Cyclohexanepropanoic acid, 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-, cis-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Cook JJ, et al. J Neurosci. 2010 May 12;30(19):6743-50. 2. Previs RA, et al. Clin Cancer Res. 2015 Mar 1;21(5):955-61. 3. Brana I, et al. Br J Cancer. 2014 Nov 11;111(10):1932-44.
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