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BMS-299897
CAS No. 290315-45-6
BMS-299897 ( BMS 299897;BMS299897 )
Catalog No. M13893 CAS No. 290315-45-6
A potent γ-secretase inhibitor that preferentially inhibits cleavage of the APP CTF cleavage with IC50 of 7.1 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 47 | Get Quote |
|
| 10MG | 87 | Get Quote |
|
| 25MG | 160 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameBMS-299897
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NoteResearch use only, not for human use.
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Brief DescriptionA potent γ-secretase inhibitor that preferentially inhibits cleavage of the APP CTF cleavage with IC50 of 7.1 nM.
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DescriptionA potent γ-secretase inhibitor that preferentially inhibits cleavage of the APP CTF cleavage with IC50 of 7.1 nM; 15-fold lower IC50 value for Notch-1 cleavage (IC50=105.9 nM) in vitro; alleviates Aβ1-42 seeding and short-term memory deficits in the Aβ25-35 mouse model of Alzheimer's disease.Alzheimer's Disease Discontinued
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SynonymsBMS 299897;BMS299897
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PathwayWnt/Notch/Hedgehog
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Targetγ-secretase
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Recptorγ-secretase
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Research AreaNeurological Disease
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IndicationAlzheimer Disease
Chemical Information
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CAS Number290315-45-6
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Formula Weight511.94
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Molecular FormulaC24H21ClF3NO4S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 30 mg/mL
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SMILESO=C(O)CCCC1=CC(F)=CC=C1[C@H](N(C2=CC(F)=CC=C2F)S(=O)(C3=CC=C(Cl)C=C3)=O)C
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Chemical NameBenzenebutanoic acid, 2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoro-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Barten DM, et al. J Pharmacol Exp Ther. 2005 Feb;312(2):635-43.
2. Meunier J, et al. Eur J Pharmacol. 2013 Jan 5;698(1-3):193-9.
3. Goldstein ME, et al. J Pharmacol Exp Ther. 2007 Oct;323(1):102-8.
2. Meunier J, et al. Eur J Pharmacol. 2013 Jan 5;698(1-3):193-9.
3. Goldstein ME, et al. J Pharmacol Exp Ther. 2007 Oct;323(1):102-8.
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