MIV-6R ( MIV-6R; MIV 6R; MIV6R; VU0516310-1; VU0516310 1; VU05163101 )

Catalog No. M12220 CAS No. 1560968-55-9

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Datasheet

HNMR

HPLC

MSDS

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Product Name

MIV-6R
Note

Research use only, not for human use.
Brief Description

A potent, ligand-efficient, and cell-active inhibitor menin-MLL interaction with IC50 of 56 nM, Kd of 85 nM.
Description

A potent, ligand-efficient, and cell-active inhibitor menin-MLL interaction with IC50 of 56 nM, Kd of 85 nM; demonstrateds strong and selective effects in MLL leukemia cells, and induces more pronounced increase in CD11b expression in MLL-AF9 BMCs.
Synonyms

MIV-6R; MIV 6R; MIV6R; VU0516310-1; VU0516310 1; VU05163101
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

——
Indication

——

CAS Number

1560968-55-9
Formula Weight

417.59
Molecular Formula

C27H35N3O
Purity

>98% (HPLC)
Solubility

——
SMILES

N#CC1=CC=C(OCCCN2CCC([C@@](C3CCCC3)(N)C4=CC=CC=C4)CC2)C=C1
Chemical Name

(R)-4-(3-(4-(amino(cyclopentyl)(phenyl)methyl)piperidin-1-yl)propoxy)benzonitrile

1. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14.
2. He S, et al. J Med Chem. 2014 Feb 27;57(4):1543-56.

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