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T1551
CAS No. 913691-90-4
T1551 ( T 1551;T-1551 )
Catalog No. M16565 CAS No. 913691-90-4
T1551 is a novel, potent and specific PRMT5 inhibitor with IC50 of 34.1 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameT1551
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NoteResearch use only, not for human use.
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Brief DescriptionT1551 is a novel, potent and specific PRMT5 inhibitor with IC50 of 34.1 uM.
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DescriptionT1551 is a novel, potent and specific PRMT5 inhibitor with IC50 of 34.1 uM, exhibits anti-proliferation on A549 cell with IC50 of 11.2 uM; reduces symmetric dimethylation level of H4R3, downregulates the protein expressions of two target genes of PRMT5, FGFR3, and eIF4E, and inhibits the activation of PI3K/AKT/mTOR and ERK signaling.
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SynonymsT 1551;T-1551
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorHMTase
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Research Area——
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Indication——
Chemical Information
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CAS Number913691-90-4
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Formula Weight302.40
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Molecular FormulaC16H24N5O+
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Purity>98% (HPLC)
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Solubility——
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SMILESCCCCC[NH+]=C(N)NN=CC1=CNC2=C1C=C(C=C2)CO
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Chemical NameN-((E)-amino(2-(((Z)-5-(hydroxymethyl)-3H-indol-3-ylidene)methyl)hydrazinyl)methylene)pentan-1-aminium
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang Q, et al. Front Pharmacol. 2018 Mar 1;9:173.
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