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EPZ015666
CAS No. 1616391-65-1
EPZ015666 ( EPZ-015666;GSK3235025 )
Catalog No. M12359 CAS No. 1616391-65-1
EPZ015666 (GSK3235025) is a potent, selective, orally available inhibitor of PRMT5 with Ki/IC50 of 5/22 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 50 | In Stock |
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| 5MG | 77 | In Stock |
|
| 10MG | 113 | In Stock |
|
| 50MG | 332 | In Stock |
|
| 100MG | 478 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameEPZ015666
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NoteResearch use only, not for human use.
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Brief DescriptionEPZ015666 (GSK3235025) is a potent, selective, orally available inhibitor of PRMT5 with Ki/IC50 of 5/22 nM.
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DescriptionEPZ015666 (GSK3235025) is a potent, selective, orally available inhibitor of PRMT5 with Ki/IC50 of 5/22 nM, displays broad selectivity against a panel of other histone methyltransferases; inhibits SmD3 methylation and causes cell death in MCL cell lines (IC50=61-904 nM), demonstrates potent concentration-dependent antiproliferative effects against Z-138 and Maver-1 cells with IC50 of 96 and 450 nM, respectively; exhibits antitumor activity in multiple MCL xenograft models.
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SynonymsEPZ-015666;GSK3235025
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorPRMT5
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1616391-65-1
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Formula Weight383.44
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Molecular FormulaC20H25N5O3
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Purity>98% (HPLC)
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SolubilityDMSO
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SMILESO=C(C1=NC=NC(NC2COC2)=C1)NC[C@H](O)CN3CC4=C(C=CC=C4)CC3
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Chemical Name4-Pyrimidinecarboxamide, N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chan-Penebre E, et al. Nat Chem Biol. 2015 Jun;11(6):432-7.
2. Kryukov GV, et al. Science. 2016 Mar 11;351(6278):1214-8.
3. Chan-Penebre E, et al. ACS Med Chem Lett. 2015 Dec 2;7(2):162-6.
4. Gullà A, et al. Leukemia. 2018 Apr;32(4):996-1002.
2. Kryukov GV, et al. Science. 2016 Mar 11;351(6278):1214-8.
3. Chan-Penebre E, et al. ACS Med Chem Lett. 2015 Dec 2;7(2):162-6.
4. Gullà A, et al. Leukemia. 2018 Apr;32(4):996-1002.
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