SGC0946 ( SGC-0946; SGC 0946; SGC0946. )

Catalog No. M12221 CAS No. 1561178-17-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SGC0946
Note

Research use only, not for human use.
Brief Description

SGC0946 is a highly potent and selective DOT1L methyltransferase inhibitor with IC50 of 0.3 nM; selectively kill mixed lineage leukaemia cells.
Description

SGC0946 is a highly potent and selective DOT1L methyltransferase inhibitor with IC50 of 0.3 nM; selectively kill mixed lineage leukaemia cells.
Synonyms

SGC-0946; SGC 0946; SGC0946.
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

DOT1L
Research Area

Cancer
Indication

——

CAS Number

1561178-17-3
Formula Weight

618.57
Molecular Formula

C28H40BrN7O4
Purity

>98%(HPLC)
Solubility

Ethanol: 100 mg/mL (161.66 mM); DMSO: 100 mg/mL (161.66 mM)
SMILES

O=C(NC1=CC=C(CC(C)C)C=C1)NCCCN(C[C@H]2O[C@@H](N3C=C(Br)C4=C(N)N=CN=C43)[C@H](O)[C@@H]2O)C(C)C
Chemical Name

1-(3-((((2R,3S,4R,5R)-5-(4-amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-isobutylphenyl)urea

1. Yu W, et al. nat Commun. 2012;3:1288.

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