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MI-503
CAS No. 1857417-13-0
MI-503( MI 503 | MI503 )
Catalog No. M12868 CAS No. 1857417-13-0
A highly potent and orally bioavailable small-molecule inhibitor of Menin-MLL interaction with Kd of 9.3 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 105 | Get Quote |
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| 5MG | 197 | Get Quote |
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| 10MG | 329 | Get Quote |
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| 25MG | 493 | Get Quote |
|
| 50MG | 710 | Get Quote |
|
| 100MG | 981 | Get Quote |
|
| 200MG | 1332 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMI-503
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NoteResearch use only, not for human use.
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Brief DescriptionA highly potent and orally bioavailable small-molecule inhibitor of Menin-MLL interaction with Kd of 9.3 nM.
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DescriptionA highly potent and orally bioavailable small-molecule inhibitor of Menin-MLL interaction with Kd of 9.3 nM; effectively induces differentiation of MLL leukemia cells and and substantially increases expression of CD11b, also reduces expression of Hoxa9 and Meis1; induces marked anti-proliferative effects in MV4;11 cells with GI50 of 200 nM; blocks hematologic tumors in vivo and reduces MLL leukemia tumor burden in mouse models.Blood Cancer Preclinical.
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In Vitro——
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In Vivo——
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SynonymsMI 503 | MI503
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorHMTase
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number1857417-13-0
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Formula Weight564.6278
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Molecular FormulaC28H27F3N8S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESN#CC(N1CC2=CNN=C2)=CC3=C1C=CC(CN4CCC(NC5=C(C=C(CC(F)(F)F)S6)C6=NC=N5)CC4)=C3C
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Chemical Name1-((1H-pyrazol-4-yl)methyl)-4-methyl-5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Borkin D, et al. Cancer Cell. 2015 Apr 13;27(4):589-602.
2. Svoboda LK, et al. Oncotarget. 2017 Jan 3;8(1):458-471.
molnova catalog
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