MI-538 ( MI538;MI 538 )

Catalog No. M12867 CAS No. 1857417-10-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MI-538
Note

Research use only, not for human use.
Brief Description

MI-538 is potent and selective menin–MLL interaction inhibitor (IC50=21 nM).
Description

MI-538 is potent and selective menin–MLL interaction inhibitor (IC50=21 nM); shows the most potent binding affinity to menin (Kd = 6.5 nM) obtained for small molecule menin–MLL inhibitor reported to date; exhibits significantly increased activity, selectivity, polarity and pharmacokinetic profile over MI-136 and demonstrates a pronounced effect in a mouse model of MLL leukemia.
Synonyms

MI538;MI 538
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

Cancer
Indication

——

CAS Number

1857417-10-7
Formula Weight

566.60
Molecular Formula

C27H25F3N8OS
Purity

>98% (HPLC)
Solubility

DMSO; Need ultrasonic and warming
SMILES

N#CC(N1CC2=CNN=C2)=CC3=C1C=C(O)C(CN4CCC(NC5=C(C=C(CC(F)(F)F)S6)C6=NC=N5)CC4)=C3
Chemical Name

1H-Indole-2-carbonitrile, 6-hydroxy-1-(1H-pyrazol-4-ylmethyl)-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-

1. Borkin D, et al. J Med Chem. 2016 Feb 11;59(3):892-913.

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