PR5-LL-CM01 ( PR5-LL-CM01 )

Catalog No. M10045 CAS No. 1005307-86-7

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Datasheet

HNMR

HPLC

MSDS

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Product Name

PR5-LL-CM01
Note

Research use only, not for human use.
Brief Description

PR5-LL-CM01 is a novel selective, small-molecule inhibitor of PRMT5 methyltransferase with IC50 of 7.5 uM.
Description

PR5-LL-CM01 is a novel selective, small-molecule inhibitor of PRMT5 methyltransferase with IC50 of 7.5 uM; displays >10-fold selectivity over PRMT3, and no inhibitory activity over PRMT1/4/6/8; exhibits cell viability inhibition with IC50 of 2-4 uM in PDAC cells, IC50 of 10-11 uM in CRC cells, more potent than EPZ015666; significantly inhibits NF-κB activation in PDAC and CRC cells, and shows dramatic anti-tumor efficacy in vivo.
Synonyms

PR5-LL-CM01
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

——
Indication

——

CAS Number

1005307-86-7
Formula Weight

401.52
Molecular Formula

C23H27N7
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1=CC=C(NC2=C3C(N(C4=CC=CC=C4)N=C3)=NC(NCCN(C)C)=N2)C=C1C
Chemical Name

N6-(2-(dimethylamino)ethyl)-N4-(3,4-dimethylphenyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

1. Prabhu L, et al. Oncotarget. 2017 Jun 20;8(25):39963-39977.

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