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MAL3-101
CAS No. 912361-26-3
MAL3-101( —— )
Catalog No. M16547 CAS No. 912361-26-3
MAL3-101 is a Hsc70 modulator that inhibits Hsp70 ATPase activity, exhibits antiproliferative activity in breast cancer cells SK-BR-3 with IC50 of 27 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameMAL3-101
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NoteResearch use only, not for human use.
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Brief DescriptionMAL3-101 is a Hsc70 modulator that inhibits Hsp70 ATPase activity, exhibits antiproliferative activity in breast cancer cells SK-BR-3 with IC50 of 27 uM.
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DescriptionMAL3-101 is a Hsc70 modulator that inhibits Hsp70 ATPase activity, exhibits antiproliferative activity in breast cancer cells SK-BR-3 with IC50 of 27 uM; also exhibits antimyeloma effects on MM cell lines in vitro and in vivo in a xenograft plasmacytoma model, as well as on primary tumor cells and bone marrow endothelial cells from myeloma patients.
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In VitroMAL3-101 (10 μM; 24, 48, 72 hours) induces cell viability in MIBC cell lines UMUC3, T24, SW780 and J82.
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In Vivo——
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Synonyms——
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetHSP
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RecptorHSP
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Research Area——
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Indication——
Chemical Information
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CAS Number912361-26-3
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Formula Weight931.14
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Molecular FormulaC54H66N4O10
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (53.70 mM)
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SMILES——
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Chemical Name5-Pyrimidinecarboxylic acid, 4-[1,1'-biphenyl]-2-yl-1-[6-[[2-(butylamino)-1-[3-(methoxycarbonyl)-4-(2-methoxy-2-oxoethoxy)phenyl]-2-oxoethyl]hexylamino]-6-oxohexyl]-1,2,3,4-tetrahydro-6-methyl-2-oxo-, phenylmethyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fewell SW, et al. J Biol Chem. 2004 Dec 3;279(49):51131-40.
2. Huryn DM, et al. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6757-62.
3. Braunstein MJ, et al. J Oncol. 2011;2011:232037. doi: 10.1155/2011/232037.
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