BLU-945( —— )

Catalog No. M37656 CAS No. 2660250-10-0

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Product Name

BLU-945
Note

Research use only, not for human use.
Brief Description

BLU-945 is a reversible, potent, highly selective, and orally available epidermal growth factor receptor tyrosine kinase inhibitor (TKIs).
Description

BLU-945 is a potent, highly selective, reversible and orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKIs). BLU-945 can effectively inhibit EGFR with L858R and/or exon 19 deletion mutation, T790M mutation and C797S mutation. BLU-945 can be used for the research of lung cancer including non-small cell lung cancer (NSCLC).
In Vitro

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In Vivo

Animal Model:triple-mutant osimertinib-resistant Ba/F3 CDX and PDCX models Dosage:0-100 mg/kg Administration:oral, twice daily Result:Showed significant tumor regression in an osimertinib-resistant EGFR ex19del/T790M/C797S PDCX.
Synonyms

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Pathway

Angiogenesis
Target

EGFR
Recptor

EGFR
Research Area

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Indication

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CAS Number

2660250-10-0
Formula Weight

556.7
Molecular Formula

C28H37FN6O3S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (179.63 mM; Ultrasonic )
SMILES

CO[C@@H]1CCN(C[C@@H]1F)c1nccc(Nc2cc3c(ccc(N4C[C@H](CS(C)(=O)=O)[C@H]4C)c3cn2)C(C)C)n1
Chemical Name

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1. John Emmerson Campbell, et al. Inhibitors of mutant forms of egfr. Patent WO2021133809A1.

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