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AG-825
CAS No. 149092-50-2
AG-825( —— )
Catalog No. M33258 CAS No. 149092-50-2
AG-825（Tyrphostin C15） is a selective and competitive ErbB2 inhibitor that inhibits tyrosine phosphorylation with an IC50 value of 0.35 μM.AG-825 (Tyrphostin C15) inhibits HER2 and shows anticancer activity in a mouse xenograft model of breast cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 67 | In Stock |
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| 5MG | 61 | In Stock |
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| 10MG | 107 | In Stock |
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| 25MG | 235 | In Stock |
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| 50MG | 384 | In Stock |
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| 100MG | 617 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 1274 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAG-825
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NoteResearch use only, not for human use.
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Brief DescriptionAG-825（Tyrphostin C15） is a selective and competitive ErbB2 inhibitor that inhibits tyrosine phosphorylation with an IC50 value of 0.35 μM.AG-825 (Tyrphostin C15) inhibits HER2 and shows anticancer activity in a mouse xenograft model of breast cancer.
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DescriptionAG-825 (Tyrphostin AG-825) is a selective and ATP-competitive ErbB2 inhibitor which suppresses tyrosine phosphorylation, with an IC50 of 0.35 μM. AG-825 displays anti-cancer activity.AG825 significantly accelerates apoptosis of human neutrophils. AG-825 is a potential agent for overcoming Mn-induced neurotoxicity or AD development.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR | Apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number149092-50-2
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Formula Weight397.47
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Molecular FormulaC19H15N3O3S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (628.98 mM; Ultrasonic )
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SMILESCOc1cc(\C=C(/C#N)C(N)=O)cc(CSc2nc3ccccc3s2)c1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wolfson E, et al. Nucleolin and ErbB2 inhibition reduces tumorigenicity of ErbB2-positive breast cancer. Cell Death Dis. 2018 Jan 19;9(2):47.?
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