Cart
sales@molnova.com
AG-825
CAS No. 149092-50-2
AG-825( —— )
Catalog No. M33258 CAS No. 149092-50-2
AG-825（Tyrphostin C15） is a selective and competitive ErbB2 inhibitor that inhibits tyrosine phosphorylation with an IC50 value of 0.35 μM.AG-825 (Tyrphostin C15) inhibits HER2 and shows anticancer activity in a mouse xenograft model of breast cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 67 | In Stock |
|
| 5MG | 61 | In Stock |
|
| 10MG | 107 | In Stock |
|
| 25MG | 235 | In Stock |
|
| 50MG | 384 | In Stock |
|
| 100MG | 617 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1274 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameAG-825
-
NoteResearch use only, not for human use.
-
Brief DescriptionAG-825（Tyrphostin C15） is a selective and competitive ErbB2 inhibitor that inhibits tyrosine phosphorylation with an IC50 value of 0.35 μM.AG-825 (Tyrphostin C15) inhibits HER2 and shows anticancer activity in a mouse xenograft model of breast cancer.
-
DescriptionAG-825 (Tyrphostin AG-825) is a selective and ATP-competitive ErbB2 inhibitor which suppresses tyrosine phosphorylation, with an IC50 of 0.35 μM. AG-825 displays anti-cancer activity.AG825 significantly accelerates apoptosis of human neutrophils. AG-825 is a potential agent for overcoming Mn-induced neurotoxicity or AD development.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayAngiogenesis
-
TargetEGFR
-
RecptorEGFR | Apoptosis
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number149092-50-2
-
Formula Weight397.47
-
Molecular FormulaC19H15N3O3S2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 250 mg/mL (628.98 mM; Ultrasonic )
-
SMILESCOc1cc(\C=C(/C#N)C(N)=O)cc(CSc2nc3ccccc3s2)c1O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Wolfson E, et al. Nucleolin and ErbB2 inhibition reduces tumorigenicity of ErbB2-positive breast cancer. Cell Death Dis. 2018 Jan 19;9(2):47.?
molnova catalog
related products
-
EGFR-IN-1 hydrochlor...
EGFR-IN-1 hydrochloride is an irreversible and specific inhibitor of L858R/T790M mutant EGFR, with 100-fold selectivity over wild-type EGFR.
-
Orphenadrine Citrate
Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.
-
Cloperastine fendizo...
Cloperastine fendizoate (Hustazol) inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).
