ZM 323881 hydrochloride

Research use only, not for human use.

ZZZM 323881 hydrochloride is a potent and selective VEGFR2 inhibitor with IC50 of <2 nM, almost no activity on VEGFR1, PDGFRβ, FGFR1, EGFR and ErbB2.

ZZZM 323881 hydrochloride is a potent and selective VEGFR2 inhibitor with IC50 of <2 nM, almost no activity on VEGFR1, PDGFRβ, FGFR1, EGFR and ErbB2.

ZM323881 is an anilinoquinazoline that potently inhibits VEGFR2 (KDR) tyrosine kinase activity anddemonstrates excellent selectivity versus other receptor tyrosine kinases, including PDGFRβ, FGFR1, EGFR and erbB2 (IC50>50 μM). ZM323881 inhibits VEGF-A-induced endothelial cell proliferation(IC50=8 nM) and VEGFR2 tyrosine phosphorylation. ZM323881 inhibits activation of VEGFR-2, but not of VEGFR-1, epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR), or hepatocyte growth factor (HGF) receptor. In HAECs, ZM323881 completely inhibits VEGF-induced ERK phosphorylation at 1 μM.

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Angiogenesis

EGFR

EGFR| FGFR1| PDGFRβ| VEGFR1| VEGFR2

Cancer

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193000-39-4

411.86

C22H19ClFN3O2

>98% (HPLC)

DMSO: 10 mg/mL (24.28 mM)

Cl.CC1=CC(F)=C(NC2=NC=NC3=C2C=CC(OCC2=CC=CC=C2)=C3)C=C1O

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(-20℃)

With Ice Pack

≥ 2 years