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TX1-85-1

CAS No. 1603845-32-4

TX1-85-1( —— )

Catalog No. M23702 CAS No. 1603845-32-4

TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TX1-85-1
  • Note
    Research use only, not for human use.
  • Brief Description
    TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling.
  • Description
    TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling. TX1-85-1 is an irreversible Her3 inhibitor (IC50: 23 nM). TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3.
  • In Vitro
    TX1-85-1 possesses an anti-proliferation EC50s of 9.9, 11.5, and 16.9 μM for Ovcar8, HCC827 GR6, and PC9 GR4 cells, respectively.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    ErbB3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1603845-32-4
  • Formula Weight
    580.68
  • Molecular Formula
    C32H36N8O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:3.85 mg/mL (6.63 mM; Need ultrasonic)
  • SMILES
    CC(N1CCN(C2CCC(N3N=C(C4=CC(NC(C=C)=O)=C(OC5=CC=CC=C5)C=C4)C6=C3N=CN=C6N)CC2)CC1)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Xie T, et al. Pharmacological targeting of the pseudokinase Her3. Nat Chem Biol. 2014 Dec;10(12):1006-12.
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