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TX1-85-1
CAS No. 1603845-32-4
TX1-85-1( —— )
Catalog No. M23702 CAS No. 1603845-32-4
TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 140 | In Stock |
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| 10MG | 250 | In Stock |
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| 25MG | 401 | In Stock |
|
| 50MG | 591 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTX1-85-1
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NoteResearch use only, not for human use.
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Brief DescriptionTX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling.
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DescriptionTX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling. TX1-85-1 is an irreversible Her3 inhibitor (IC50: 23 nM). TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3.
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In VitroTX1-85-1 possesses an anti-proliferation EC50s of 9.9, 11.5, and 16.9 μM for Ovcar8, HCC827 GR6, and PC9 GR4 cells, respectively.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetEGFR
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RecptorErbB3
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Research Area——
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Indication——
Chemical Information
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CAS Number1603845-32-4
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Formula Weight580.68
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Molecular FormulaC32H36N8O3
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Purity>98% (HPLC)
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SolubilityDMSO:3.85 mg/mL (6.63 mM; Need ultrasonic)
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SMILESCC(N1CCN(C2CCC(N3N=C(C4=CC(NC(C=C)=O)=C(OC5=CC=CC=C5)C=C4)C6=C3N=CN=C6N)CC2)CC1)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Xie T, et al. Pharmacological targeting of the pseudokinase Her3. Nat Chem Biol. 2014 Dec;10(12):1006-12.
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