NLRP3 agonist 1( —— )

Catalog No. M37305 CAS No. 2454019-69-1

NLRP3 agonist 1 (compound 23) is a potent, orally active agent that activates Caspase-1 enzyme, resulting in the cleavage of proinflammatory cytokines pro-IL-1β and pro-IL-18 into their active forms .

Purity : >98% (HPLC)

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Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

NLRP3 agonist 1
Note

Research use only, not for human use.
Brief Description

NLRP3 agonist 1 (compound 23) is a potent, orally active agent that activates Caspase-1 enzyme, resulting in the cleavage of proinflammatory cytokines pro-IL-1β and pro-IL-18 into their active forms .
Description

NLRP3 agonist 1 (compound 23) is a potent and orally active NLRP3 agonist. NLRP3 agonist 1 can activate the enzyme Caspase-1 to cleave pro-IL-1β and pro-IL-18 proinflammatory cytokines into their mature forms.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

NF-κB
Target

NOD
Recptor

NOD-like Receptor (NLR)
Research Area

——
Indication

——

Chemical Information

CAS Number

2454019-69-1
Formula Weight

280.33
Molecular Formula

C15H16N6
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (356.72 mM; Ultrasonic (<80°C)
SMILES

N=1NC=CC1C=2C=CC3=C(N=C(N=C3NC4(C)CC4)N)C2
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. O' Donovan DH, et, al. Discovery and characterisation of quinazolines and 8-Azaquinazolines as NLRP3 agonists with oral bioavailability in mice. Bioorg Med Chem Lett. 2023 Oct 12:96:129518.?

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