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NT-0796
CAS No. 2272917-13-0
NT-0796( —— )
Catalog No. M37302 CAS No. 2272917-13-0
NT-0796 is a brain-permeable, potent, and selective inhibitor of the inflammasome NLRP3, inhibiting NLRP3 activation.NT-0796 is a potential NDT-19795 delivery vector.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 471 | In Stock |
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| 10MG | 753 | In Stock |
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| 25MG | 1121 | In Stock |
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| 50MG | 1516 | In Stock |
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| 100MG | 2037 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameNT-0796
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NoteResearch use only, not for human use.
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Brief DescriptionNT-0796 is a brain-permeable, potent, and selective inhibitor of the inflammasome NLRP3, inhibiting NLRP3 activation.NT-0796 is a potential NDT-19795 delivery vector.
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DescriptionNT-0796 is a selective and CNS-penetrant NLRP3 inflammasome inhibitor with an IC50 of 0.32 nM in PBMC assay. NT-0796 is an isopropyl ester that undergoes intracellular conversion to NDT-19795, the carboxylic acid active species. NT-0796 has the potential for neuroinflammatory diseases research.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayNF-κB
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TargetNOD
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RecptorNOD
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Research Area——
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Indication——
Chemical Information
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CAS Number2272917-13-0
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Formula Weight409.48
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Molecular FormulaC23H27N3O4
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Purity>98% (HPLC)
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Solubility——
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SMILESN(C(O[C@H](CC=1N=CC=CN1)C(OC(C)C)=O)=O)C2=C3C(=CC4=C2CCC4)CCC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. David Harrison, et al. Discovery of Clinical Candidate NT-0796, a Brain-Penetrant and Highly Potent NLRP3 Inflammasome Inhibitor for Neuroinflammatory Disorders. J Med Chem. 2023 Oct 24.?
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