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I-138
CAS No. 2098211-50-6
I-138( —— )
Catalog No. M36543 CAS No. 2098211-50-6
I-138 is an orally active and potent reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 406 | In Stock |
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| 5MG | 369 | In Stock |
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| 10MG | 519 | In Stock |
|
| 25MG | 847 | In Stock |
|
| 50MG | 1181 | In Stock |
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| 100MG | 1655 | In Stock |
|
| 200MG | 2213 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameI-138
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NoteResearch use only, not for human use.
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Brief DescriptionI-138 is an orally active and potent reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.
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DescriptionI-138 is an orally active, reversible inhibitor of USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM), structurally related to ML323 (HY-17543). I-138 induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetDUB
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RecptorDUB
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Research Area——
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Indication——
Chemical Information
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CAS Number2098211-50-6
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Formula Weight492.5
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Molecular FormulaC26H23F3N6O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (203.05 mM; Ultrasonic )
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SMILESC(N1C=2C(NC1=O)=CN=C(N2)C3=C(C(C)C)C=CC=C3)C4=CC=C(C=C4)C5=NC(C(F)(F)F)=CN5C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Simoneau A, et al. Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer. Mol Cancer Ther. 2023 Feb 1;22(2):215-226.?
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