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PR-619

CAS No. 2645-32-1

PR-619( 2,6-Diamino-3,5-dithiocyanopyridine | DUB Inhibitor V )

Catalog No. M13810 CAS No. 2645-32-1

PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PR-619
  • Note
    Research use only, not for human use.
  • Brief Description
    PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay.
  • Description
    PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay.
  • In Vitro
    Cell Cytotoxicity Assay Cell Line:OLN-t40 cells.Concentration:0-10 μM.Incubation Time:24 hours.Result:Exerted concentration-dependent cytotoxicity in a very narrow concentration range of 7-10 μM.
  • In Vivo
    Animal Model:Nude mice.Dosage:10 mg/kg/day (Cisplatin combined).Administration:Intraperitoneally.Result:Enhanced the antitumor effect of Cisplatin.
  • Synonyms
    2,6-Diamino-3,5-dithiocyanopyridine | DUB Inhibitor V
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    JOSD2| SENP6 core| UCH-L3| USP4| USP8
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    2645-32-1
  • Formula Weight
    223.33
  • Molecular Formula
    C7H5N5S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 45 mg/mL (201.54 mM)
  • SMILES
    N#CSC1=C(N)N=C(N)C(SC#N)=C1
  • Chemical Name
    (2,6-diamino-5-thiocyanatopyridin-3-yl) thiocyanate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Altun M, et al. Chem Biol, 2011, 18(11), 1401-1412.
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