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BGB-8035
CAS No. 2283349-24-4
BGB-8035( —— )
Catalog No. M36520 CAS No. 2283349-24-4
BGB-8035 is an orally available, selective and potent BTK inhibitor with antitumor activity that inhibits BTK, TEC and EGFR.BGB-8035 is used in the study of tumors and autoimmune diseases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 155 | In Stock |
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| 10MG | 231 | In Stock |
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| 25MG | 377 | In Stock |
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| 50MG | 556 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBGB-8035
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NoteResearch use only, not for human use.
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Brief DescriptionBGB-8035 is an orally available, selective and potent BTK inhibitor with antitumor activity that inhibits BTK, TEC and EGFR.BGB-8035 is used in the study of tumors and autoimmune diseases.
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DescriptionBGB-8035 is an orally active, highly selective bruton's tyrosine kinase (BTK) inhibitor with IC50s of 1.1 nM, 99 nM, 621 nM for BTK, TEC, EGFR, respectively. BGB-8035 has antitumor and anti-arthritis activity. BGB-8035 has the potential for B-cell malignancies and autoimmune diseases research.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayTyrosine Kinase
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TargetBTK
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RecptorBTK | EGFR
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Research Area——
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Indication——
Chemical Information
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CAS Number2283349-24-4
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Formula Weight453.53
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Molecular FormulaC24H31N5O4
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Purity>98% (HPLC)
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Solubility——
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SMILESC(N)(=O)C1=C2N([C@@H](CCN2)C3CCN(C(C=C)=O)CC3)N=C1C4=CC(OC)=C(C)C(OC)=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yunhang Guo, et al. Discovery of BGB-8035, a Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase for B-Cell Malignancies and Autoimmune Diseases. J Med Chem. 2023 Mar 23;66(6):4025-4044.?
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