Cart
sales@molnova.com
BGB-8035
CAS No. 2283349-24-4
BGB-8035( —— )
Catalog No. M36520 CAS No. 2283349-24-4
BGB-8035 is an orally available, selective and potent BTK inhibitor with antitumor activity that inhibits BTK, TEC and EGFR.BGB-8035 is used in the study of tumors and autoimmune diseases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 628 | Get Quote |
|
| 5MG | 933 | Get Quote |
|
| 10MG | 1254 | Get Quote |
|
| 25MG | 1812 | Get Quote |
|
| 50MG | 2374 | Get Quote |
|
| 100MG | 3060 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameBGB-8035
-
NoteResearch use only, not for human use.
-
Brief DescriptionBGB-8035 is an orally available, selective and potent BTK inhibitor with antitumor activity that inhibits BTK, TEC and EGFR.BGB-8035 is used in the study of tumors and autoimmune diseases.
-
DescriptionBGB-8035 is an orally active, highly selective bruton's tyrosine kinase (BTK) inhibitor with IC50s of 1.1 nM, 99 nM, 621 nM for BTK, TEC, EGFR, respectively. BGB-8035 has antitumor and anti-arthritis activity. BGB-8035 has the potential for B-cell malignancies and autoimmune diseases research.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayTyrosine Kinase
-
TargetBTK
-
RecptorBTK | EGFR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2283349-24-4
-
Formula Weight453.53
-
Molecular FormulaC24H31N5O4
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC(N)(=O)C1=C2N([C@@H](CCN2)C3CCN(C(C=C)=O)CC3)N=C1C4=CC(OC)=C(C)C(OC)=C4
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Yunhang Guo, et al. Discovery of BGB-8035, a Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase for B-Cell Malignancies and Autoimmune Diseases. J Med Chem. 2023 Mar 23;66(6):4025-4044.?
molnova catalog
related products
-
G-744
G-744 is a highly potent, selective inhibitor of BTK with biochemical Ki of 1.28 nM.
-
TL-895
TL-895 is an ATP-competitive, and highly selective irreversible inhibitor of Bruton’s Tyrosine Kinase(BTK). TL-895 showed good potency with an IC50 of 1.5 nM and a Ki of 11.9 nM.
-
BTK-IN-23
BTK-IN-23 is a highly potent and selective Btk inhibitor with IC50 of 3 nM.
