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TAK-020
CAS No. 1627603-21-7
TAK-020( —— )
Catalog No. M37633 CAS No. 1627603-21-7
TAK-020 is a potent covalent inhibitor of Btk with potential antitumor activity for the study of rheumatoid arthritis and immune-related diseases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 377 | In Stock |
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| 5MG | 353 | In Stock |
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| 10MG | 630 | In Stock |
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| 25MG | 1302 | In Stock |
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| 50MG | 1972 | In Stock |
|
| 100MG | 3050 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTAK-020
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NoteResearch use only, not for human use.
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Brief DescriptionTAK-020 is a potent covalent inhibitor of Btk with potential antitumor activity for the study of rheumatoid arthritis and immune-related diseases.
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DescriptionTAK-020 is a covalent Btk inhibitor, which becomes the clinical candidate.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayTyrosine Kinase
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TargetBTK
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RecptorBTK
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Research Area——
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Indication——
Chemical Information
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CAS Number1627603-21-7
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Formula Weight351.36
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Molecular FormulaC18H17N5O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 20.83 mg/mL (59.28 mM; Ultrasonic (<80°C)
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SMILESC=CC(=O)N1CC[C@@H](C1)Oc1nc(cc2ccccc12)-c1nc(=O)[nH][nH]1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sabat M, et al. Discovery of the Bruton's Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 (S)-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one, by Fragment-Based Drug Design. J Med Chem. 2021 Sep 9;64(17):12893-12902. ?
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