TAK-020( —— )

Catalog No. M37633 CAS No. 1627603-21-7

TAK-020 is a potent covalent inhibitor of Btk with potential antitumor activity for the study of rheumatoid arthritis and immune-related diseases.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	377	In Stock
5MG	353	In Stock
10MG	630	In Stock
25MG	1302	In Stock
50MG	1972	In Stock
100MG	3050	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

TAK-020
Note

Research use only, not for human use.
Brief Description

TAK-020 is a potent covalent inhibitor of Btk with potential antitumor activity for the study of rheumatoid arthritis and immune-related diseases.
Description

TAK-020 is a covalent Btk inhibitor, which becomes the clinical candidate.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Tyrosine Kinase
Target

BTK
Recptor

BTK
Research Area

——
Indication

——

Chemical Information

CAS Number

1627603-21-7
Formula Weight

351.36
Molecular Formula

C18H17N5O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 20.83 mg/mL (59.28 mM; Ultrasonic (<80°C)
SMILES

C=CC(=O)N1CC[C@@H](C1)Oc1nc(cc2ccccc12)-c1nc(=O)[nH][nH]1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Sabat M, et al. Discovery of the Bruton's Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 (S)-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one, by Fragment-Based Drug Design. J Med Chem. 2021 Sep 9;64(17):12893-12902. ?

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