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BTK
Bruton's tyrosine kinase (BTK) belongs to the Tec kinases family of tyrosine protein kinases. It is a crucial terminal kinase in the B cell receptor (BCR) signaling pathway, and essential for the development and activation of B cells. Aberrant activation of B cells is found to play a central role in the pathogenesis of B-cell lymphomas and autoimmune diseases. BTK is involved in multiple signaling pathways,and plays an important role in the B-cell receptor (BCR) signal pathway, including the PI3K, MAPK and NF-κB pathways. After BCR is first activated by phosphorylation, phosphorylated BCR recruits spleen tyrosine kinase (SYK) to the membrane, where SYK is phosphorylated and subsequently phosphorylates BTK. Activated BTK can phosphorylate PLCγ2 in Y753 and Y759, which is critical for lipase activity. BTK may be a potential target for therapy of hematological malignancies and autoimmune diseases.
References
1.Feng Y,et al. Expert Opin Ther Pat. 2019 Apr;29(4):217-241.
References
1.Feng Y,et al. Expert Opin Ther Pat. 2019 Apr;29(4):217-241.