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GNE-431
CAS No. 1433820-83-7
GNE-431( GNE431 )
Catalog No. M11843 CAS No. 1433820-83-7
GNE-431 is a potent, selective and noncovalent Btk inhibitor with IC50 of 3.2 nM and 2.5 nM for WT Btk and C481S mutant, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1323 | Get Quote |
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| 50MG | 2682 | Get Quote |
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| 100MG | 3600 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameGNE-431
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NoteResearch use only, not for human use.
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Brief DescriptionGNE-431 is a potent, selective and noncovalent Btk inhibitor with IC50 of 3.2 nM and 2.5 nM for WT Btk and C481S mutant, respectively.
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DescriptionGNE-431 is a potent, selective and noncovalent Btk inhibitor with IC50 of 3.2 nM and 2.5 nM for WT Btk and C481S mutant, respectively; shows higher selectivity for Btk than any of the covalent inhibitors or non-covalent analogs profiled; does not interact with Cys481 and differs from covalent inhibitors like ibrutinib, potently inhibits the ibrutinib-resistant Btk C481S mutant in vitro and in cells; also shows excellent potency against the C481R, T474I, and T474M mutants (IC50=7.5-10 nM); potently inhibits BCR signaling in stimulated human blood and blocks Btk autophosphorylation in C481S-transfected cells.
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In Vitro——
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In Vivo——
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SynonymsGNE431
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PathwayTyrosine Kinase
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TargetBTK
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RecptorBTK
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Research Area——
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Indication——
Chemical Information
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CAS Number1433820-83-7
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Formula Weight564.654
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Molecular FormulaC30H32N10O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1N(C2=NC=CC(C3=NN4C=CN=C4C(NC(C=C5C6)=NN5CCN6C)=C3)=C2CO)CCN7C1=CC8=C7CCCC8
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Chemical Name3,4,6,7,8,9-Hexahydro-2-[3-(hydroxymethyl)-4-[8-[(4,5,6,7-tetrahydro-5-methylpyrazolo[1,5-a]pyrazin-2-yl)amino]imidazo[1,2-b]pyridazin-6-yl]-2-pyridinyl]pyrazino[1,2-a]indol-1(2H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Johnson AR, et al. ACS Chem Biol. 2016 Oct 21;11(10):2897-2907.
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