Larotinib( —— )

Catalog No. M36515 CAS No. 1438072-11-7

Larotinib is an orally active, potent, and broad-spectrum tyrosine kinase inhibitor (TKI) with an IC50 of 0.6 nM for EGFR.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Size	Price / USD	Stock	Quantity
2MG	112	Get Quote
5MG	170	Get Quote
10MG	258	Get Quote
25MG	426	Get Quote
50MG	609	Get Quote
100MG	835	Get Quote
500MG	Get Quote	Get Quote
1G	Get Quote	Get Quote

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Biological Information

Product Name

Larotinib
Note

Research use only, not for human use.
Brief Description

Larotinib is an orally active, potent, and broad-spectrum tyrosine kinase inhibitor (TKI) with an IC50 of 0.6 nM for EGFR.
Description

Larotinib is a potent broad-spectrum and orally active tyrosine kinase inhibitor (TKI) with EGFR as the main target with an IC50 of 0.6 nM.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Tyrosine Kinase
Target

BTK
Recptor

BTK | Tyrosine Kinases | IRAK | EGFR
Research Area

——
Indication

——

Chemical Information

CAS Number

1438072-11-7
Formula Weight

488.94
Molecular Formula

C24H26ClFN4O4
Purity

>98% (HPLC)
Solubility

——
SMILES

N(C=1C2=C(C=C(OC)C(OCCCN3C[C@@]4([C@](C3)(OCCO4)[H])[H])=C2)N=CN1)C5=CC(Cl)=C(F)C=C5
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Liu J, et al. Phase I Trial to Evaluate the Tolerance, Pharmacokinetics and Efficacy of the Broad-Spectrum ErbB Family Inhibitor Larotinib Mesylate in Patients With Advanced Solid Tumors. Front Pharmacol. 2021 Feb 18;12:636324.?

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