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Tilfrinib
CAS No. 1600515-49-8
Tilfrinib( —— )
Catalog No. M26845 CAS No. 1600515-49-8
Tilfrinib is an effective and selective inhibitor of breast tumor kinase (IC50: 3.15 nM), which displays anti-proliferative activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 85 | In Stock |
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| 2MG | 51 | In Stock |
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| 5MG | 85 | In Stock |
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| 10MG | 132 | In Stock |
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| 25MG | 256 | In Stock |
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| 50MG | 454 | In Stock |
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| 100MG | 666 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | 1376 | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTilfrinib
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NoteResearch use only, not for human use.
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Brief DescriptionTilfrinib is an effective and selective inhibitor of breast tumor kinase (IC50: 3.15 nM), which displays anti-proliferative activity.
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DescriptionTilfrinib is an effective and selective inhibitor of breast tumor kinase (IC50: 3.15 nM), which displays anti-proliferative activity.(In Vitro):Tilfrinib is against MCF7, HS-578/T, and BT-549 cells with GI50 values of 0.99, 1.02 and 1.58 μM.
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In VitroTilfrinib (20 μM; 36 h) shows inhibition of PTK6, and decreases the ETV4 WT-induced expression of CXCL1 or CXCL8 in UM-UC-3 cells and expression of VEGFA or MMP9 in TANs.Tilfrinib (compound 4f) shows good anti-proliferative activity against MCF7, HS-578/T and BT-549 cells with GI50 values of 0.99, 1.02 and 1.58 μM. Western Blot Analysis Cell Line:UM-UC-3 cells (stably expressing FLAG-ETV4 WT or Y392F)Concentration:20 μM Incubation Time:36 h Result:Reduced ETV4 WT-induced expression of CXCL1 or CXCL8 in UM-UC-3 cells and expression of VEGFA or MMP9 in TANs by inhibiting PTK6.
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In Vivo——
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Synonyms——
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PathwayTyrosine Kinase
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TargetBTK
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RecptorNav1.7 channel
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Research Area——
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Indication——
Chemical Information
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CAS Number1600515-49-8
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Formula Weight275.311
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Molecular FormulaC17H13N3O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (454.05 mM)
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SMILESOc1cccc(Nc2ccnc3[nH]c4ccccc4c23)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Shinozuka T, et al. Discovery of DS-1971a, a Potent, Selective NaV1.7 Inhibitor [published online ahead of print, 2020 May 26]. J Med Chem. 2020;10.1021/acs.jmedchem.0c00259.
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