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Enerisant
CAS No. 1152747-82-4
Enerisant( —— )
Catalog No. M36010 CAS No. 1152747-82-4
Enerisant (TS-091) is an orally active, selective and potent histamine H3 receptor antagonist that modulates histamine H3 receptors in mice in a dose-dependent manner.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 113 | In Stock |
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| 2MG | 62 | In Stock |
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| 5MG | 104 | In Stock |
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| 10MG | 169 | In Stock |
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| 25MG | 358 | In Stock |
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| 50MG | 453 | In Stock |
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| 100MG | 631 | In Stock |
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| 200MG | 854 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameEnerisant
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NoteResearch use only, not for human use.
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Brief DescriptionEnerisant (TS-091) is an orally active, selective and potent histamine H3 receptor antagonist that modulates histamine H3 receptors in mice in a dose-dependent manner.
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DescriptionEnerisant (TS-091) is a potent, highly selective, competitive and orally active histamine H3 receptor antagonist/inverse agonist with IC50s of 2.89 nM and 14.5 nM against human and rat histamine H3 receptors, respectively.
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In Vitro——
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In VivoAnimal Model:Male SD rats, R-α-methylhistamine-induced dipsogenia model Dosage:0.1, 0.3 and 1 mg/kg Administration:Oral, single dose Result:Attenuated the dipsogenia response, reaching statistical significance at doses of 0.3 mg/kg and 1 mg/kg.
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Synonyms——
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PathwayGPCR/G Protein
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TargetHistamine Receptor
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RecptorHistamine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1152747-82-4
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Formula Weight398.5
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Molecular FormulaC22H30N4O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (250.94 mM; Ultrasonic )
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SMILESC(=O)(C1=CN(N=C1)C2=CC=C(OCCCN3[C@H](C)CCC3)C=C2)N4CCOCC4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hino N, et al. A novel potent and selective histamine H3 receptor antagonist enerisant: in vitro profiles, in vivo receptor occupancy, and wake-promoting and procognitive effects in rodents. Journal of Pharmacology and Experimental Therapeutics, 2020, 375(2): 276-285.
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