Cart
sales@molnova.com
Enerisant
CAS No. 1152747-82-4
Enerisant( —— )
Catalog No. M36010 CAS No. 1152747-82-4
Enerisant (TS-091) is an orally active, selective and potent histamine H3 receptor antagonist that modulates histamine H3 receptors in mice in a dose-dependent manner.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 113 | In Stock |
|
| 2MG | 62 | In Stock |
|
| 5MG | 104 | In Stock |
|
| 10MG | 169 | In Stock |
|
| 25MG | 358 | In Stock |
|
| 50MG | 453 | In Stock |
|
| 100MG | 631 | In Stock |
|
| 200MG | 854 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameEnerisant
-
NoteResearch use only, not for human use.
-
Brief DescriptionEnerisant (TS-091) is an orally active, selective and potent histamine H3 receptor antagonist that modulates histamine H3 receptors in mice in a dose-dependent manner.
-
DescriptionEnerisant (TS-091) is a potent, highly selective, competitive and orally active histamine H3 receptor antagonist/inverse agonist with IC50s of 2.89 nM and 14.5 nM against human and rat histamine H3 receptors, respectively.
-
In Vitro——
-
In VivoAnimal Model:Male SD rats, R-α-methylhistamine-induced dipsogenia model Dosage:0.1, 0.3 and 1 mg/kg Administration:Oral, single dose Result:Attenuated the dipsogenia response, reaching statistical significance at doses of 0.3 mg/kg and 1 mg/kg.
-
Synonyms——
-
PathwayGPCR/G Protein
-
TargetHistamine Receptor
-
RecptorHistamine Receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1152747-82-4
-
Formula Weight398.5
-
Molecular FormulaC22H30N4O3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (250.94 mM; Ultrasonic )
-
SMILESC(=O)(C1=CN(N=C1)C2=CC=C(OCCCN3[C@H](C)CCC3)C=C2)N4CCOCC4
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Hino N, et al. A novel potent and selective histamine H3 receptor antagonist enerisant: in vitro profiles, in vivo receptor occupancy, and wake-promoting and procognitive effects in rodents. Journal of Pharmacology and Experimental Therapeutics, 2020, 375(2): 276-285.
molnova catalog
related products
-
Vapitadine
Vapitadine is a non-sedative antihistamine compound that relieves itching caused by atopic dermatitis.
-
Sufotidine
Sufotidine (AH 25352X) is a highly selective competitive H2 receptor antagonist.
-
LML-134
LML-134 is an inverse agonist of Histamine 3 receptor (H3R)(hH3R cAMP and hH3R bdg with Kis of 0.3 nM and 12 nM).
