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Enerisant

CAS No. 1152747-82-4

Enerisant( —— )

Catalog No. M36010 CAS No. 1152747-82-4

Enerisant (TS-091) is an orally active, selective and potent histamine H3 receptor antagonist that modulates histamine H3 receptors in mice in a dose-dependent manner.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 113 In Stock
2MG 62 In Stock
5MG 104 In Stock
10MG 169 In Stock
25MG 358 In Stock
50MG 453 In Stock
100MG 631 In Stock
200MG 854 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Enerisant
  • Note
    Research use only, not for human use.
  • Brief Description
    Enerisant (TS-091) is an orally active, selective and potent histamine H3 receptor antagonist that modulates histamine H3 receptors in mice in a dose-dependent manner.
  • Description
    Enerisant (TS-091) is a potent, highly selective, competitive and orally active histamine H3 receptor antagonist/inverse agonist with IC50s of 2.89 nM and 14.5 nM against human and rat histamine H3 receptors, respectively.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male SD rats, R-α-methylhistamine-induced dipsogenia model Dosage:0.1, 0.3 and 1 mg/kg Administration:Oral, single dose Result:Attenuated the dipsogenia response, reaching statistical significance at doses of 0.3 mg/kg and 1 mg/kg.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Histamine Receptor
  • Recptor
    Histamine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1152747-82-4
  • Formula Weight
    398.5
  • Molecular Formula
    C22H30N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (250.94 mM; Ultrasonic )
  • SMILES
    C(=O)(C1=CN(N=C1)C2=CC=C(OCCCN3[C@H](C)CCC3)C=C2)N4CCOCC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hino N, et al. A novel potent and selective histamine H3 receptor antagonist enerisant: in vitro profiles, in vivo receptor occupancy, and wake-promoting and procognitive effects in rodents. Journal of Pharmacology and Experimental Therapeutics, 2020, 375(2): 276-285.
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