Abt-288( —— )

Catalog No. M34151 CAS No. 948845-91-8

ABT-288 is a selective and potent H3 antagonist for the treatment of mild to moderate Alzheimer's dementia.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Abt-288
Note

Research use only, not for human use.
Brief Description

ABT-288 is a selective and potent H3 antagonist for the treatment of mild to moderate Alzheimer's dementia.
Description

ABT-288 is a competitive, potent and selective histamine H3 receptor (H3R) antagonist. ABT-288 has Ki values of 1.9 and 8.2 nM for human and rat H3Rs, respectively. ABT-288 can be used in cognitive impairment research..
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

GPCR/G Protein
Target

Histamine Receptor
Recptor

Histamine Receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

948845-91-8
Formula Weight

372.46
Molecular Formula

C23H24N4O
Purity

>98% (HPLC)
Solubility

——
SMILES

CN1C[C@@]2(N(CC[C@@]2(C1)[H])C3=CC=C(C=C3)C4=CC=C(C=C4)N5C(=O)C=CC=N5)[H]
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Esbenshade TA, et al. Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist. J Pharmacol Exp Ther. 2012 Oct;343(1):233-45.?

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