Cart
sales@molnova.com
LML-134
CAS No. 1542135-76-1
LML-134( —— )
Catalog No. M21945 CAS No. 1542135-76-1
LML-134 is an inverse agonist of Histamine 3 receptor (H3R)(hH3R cAMP and hH3R bdg with Kis of 0.3 nM and 12 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 79 | In Stock |
|
| 5MG | 71 | In Stock |
|
| 10MG | 115 | In Stock |
|
| 25MG | 215 | In Stock |
|
| 50MG | 310 | In Stock |
|
| 100MG | 461 | In Stock |
|
| 200MG | 620 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameLML-134
-
NoteResearch use only, not for human use.
-
Brief DescriptionLML-134 is an inverse agonist of Histamine 3 receptor (H3R)(hH3R cAMP and hH3R bdg with Kis of 0.3 nM and 12 nM).
-
DescriptionLML-134 is an inverse agonist of Histamine 3 receptor (H3R)(hH3R cAMP and hH3R bdg with Kis of 0.3 nM and 12 nM). (In Vivo):LML134 (compound 18b) (oral; 10 mg/kg) indicates rapid oral absorption, with a Tmax of 0.5 hours, t1/2 of 1.54 hours and a fraction absorbed of 44%, as well as a rapid clearance in male Sprague-Dawley rats.LML134 (i.v.; 1 mg/kg) has t1/2 of 0.44 hours, CL of 28 mL/min/kg and the low plasma protein binding in male Sprague-Dawley rat (Fu =39.0%).
-
In Vitro——
-
In VivoLML134 (compound 18b) (oral; 10 mg/kg) indicates rapid oral absorption, with a Tmax of 0.5 hours, t1/2 of 1.54 hours and a fraction absorbed of 44%, as well as a rapid clearance in male Sprague-Dawley rats. LML134 (i.v.; 1 mg/kg) has t1/2 of 0.44 hours, CL of 28 mL/min/kg and the low plasma protein binding in male Sprague-Dawley rat (Fu =39.0%).
-
Synonyms——
-
PathwayGPCR/G Protein
-
TargetHistamine Receptor
-
RecptorH3 receptor
-
Research AreaNervous system
-
IndicationCircadian Rhythm Disorders
Chemical Information
-
CAS Number1542135-76-1
-
Formula Weight375.47
-
Molecular FormulaC19H29N5O3
-
Purity>98% (HPLC)
-
SolubilityDMSO:7.5 mg/ml(19.97 mM; Need ultrasonic)
-
SMILESCn1nc(ccc1=O)N1CCC(CC1)OC(=O)N1CCN(CC1)C1CCC1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Troxler T, et al. The Discovery of LML134, a Histamine H3 Receptor Inverse Agonist for the Clinical Treatment of Excessive Sleep Disorders. ChemMedChem. 2019 Jul 3;14(13):1238-1247.
molnova catalog
related products
-
3-Hydroxyflavone
3-hydroxyflavone is a member of the class of compounds known as flavonols. 3-hydroxyflavone can be found in a number of food items such as brassicas, pomegranate, red raspberry, and fenugreek. 3-hydroxyflavone is a chemical compound.
-
Lodoxamide trometham...
Lodoxamide tromethamine is a mast cell stabilizer with anti-allergic properties and can be used in studies about the treatment of asthma and allergic conjunctivitis.
-
Bicyclol
Bicyclol(SY 801) is an anti-hepatitis drug. Oral administration of bicyclol normalizes the elevated serum transaminases (ALT, AST) by 50% in chronic viral hepatitis B and C, and also has a certain level of inhibiting HBV and HCV replication.
