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Anti-inflammatory agent 36
CAS No. 2293951-01-4
Anti-inflammatory agent 36( —— )
Catalog No. M35803 CAS No. 2293951-01-4
Anti-inflammatory agent 36 is an anti-inflammatory agent that exhibited dose-dependent inhibition of LPS-induced release of TNF-a and IL-6 in active RAW 264.7 mouse macrophages (IC50 = 3.69 μM and 3.68 μM, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 51 | In Stock |
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| 5MG | 41 | In Stock |
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| 10MG | 69 | In Stock |
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| 25MG | 136 | In Stock |
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| 50MG | 216 | In Stock |
|
| 100MG | 322 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAnti-inflammatory agent 36
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NoteResearch use only, not for human use.
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Brief DescriptionAnti-inflammatory agent 36 is an anti-inflammatory agent that exhibited dose-dependent inhibition of LPS-induced release of TNF-a and IL-6 in active RAW 264.7 mouse macrophages (IC50 = 3.69 μM and 3.68 μM, respectively).
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DescriptionAnti-inflammatory agent 36 is an anti-inflammatory agent. Anti-inflammatory agent 36 inhibits LPS-induced macrophage activation.
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In VitroWestern Blot Analysis Cell Line:RAW 264.7 mouse macrophages Concentration:10 μM Incubation Time:0.5 h Result:Markedly inhibited P-P38 and P-ERK, indicating the suppression of MAPK signaling.
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In VivoAnimal Model:Acute lung injury mouse model Dosage:10 mg/kg Administration:i.p.Result:Reduced wet/dry weight ratio of the mice lungs.Reduced biomarkers of lymphocytes and macrophages.Suppresses TNF-α, IL-6, IL-1β, 7 VACM-1 and ICAM-1 level.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorImmunology/Inflammation related
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Research Area——
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Indication——
Chemical Information
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CAS Number2293951-01-4
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Formula Weight453.48
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Molecular FormulaC25H27NO7
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (55.13 mM; Ultrasonic (<60°C)
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SMILESCOc1cc(\C=C\C(=O)N2CCC\C(=C/c3cc(OC)c(OC)c(OC)c3)C2=O)ccc1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Qian J, et al. Design and synthesis novel di-carbonyl analogs of curcumin (DACs) act as potent anti-inflammatory agents against LPS-induced acute lung injury (ALI). Eur J Med Chem. 2019 Apr 1;167:414-425. ?
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