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Mtb ATP synthase-IN-1
CAS No. 2642394-38-3
Mtb ATP synthase-IN-1( —— )
Catalog No. M35484 CAS No. 2642394-38-3
Mtb ATP synthase-IN-1 (compound 6ab) is a potent inhibitor of Mycobacterium tuberculosis (Mtb) ATP synthase (MIC = 0.452-0.499 μg/mL) that can be used in anti-mycobacterium research, showing low cytotoxicity (Vero IC 50 > 64 μg/mL) and acceptable oral bioavailability with good metabolic stability.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 52 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 46 | In Stock |
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| 10MG | 67 | In Stock |
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| 25MG | 110 | In Stock |
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| 50MG | 160 | In Stock |
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| 100MG | 235 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMtb ATP synthase-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionMtb ATP synthase-IN-1 (compound 6ab) is a potent inhibitor of Mycobacterium tuberculosis (Mtb) ATP synthase (MIC = 0.452-0.499 μg/mL) that can be used in anti-mycobacterium research, showing low cytotoxicity (Vero IC 50 > 64 μg/mL) and acceptable oral bioavailability with good metabolic stability.
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DescriptionMtb ATP synthase-IN-1 (compound 6ab) is a potent Mycobacterium tuberculosis (Mtb) ATP synthase inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb. Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC50 > 64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium.
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In Vitro——
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In VivoMtb ATP synthase-IN-1 (50 mg/kg for PO, 5 mg/kg for IV; single dosage) exhibits good metabolic stability and acceptable oral bioavailability.Pharmacokinetic Parameters of Mtb ATP synthase-IN-1 in male CD-1 mouse.Animal Model:Male CD-1 mouseDosage:50 and 5 mg/kg Administration:50 mg/kg for PO, 5 mg/kg for IV; single dosage (Pharmacokinetics Analysis) Result:Exhibited good metabolic stability and acceptable oral bioavailability.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetATPase
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RecptorATPase
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Research Area——
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Indication——
Chemical Information
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CAS Number2642394-38-3
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Formula Weight323.3
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Molecular FormulaC17H13N3O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (386.64 mM; Ultrasonic )
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SMILESO=C1C(=O)C(NCC2=NC=CC=C2)=C1NC3=CC=C4OCOC4=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Li P, et al. Design, synthesis and biological evaluation of diamino substituted cyclobut-3-ene-1,2-dione derivatives for the treatment of drug-resistant tuberculosis. Eur J Med Chem. 2020;206:112538.?
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