Cart
sales@molnova.com
Home - Products - Endocrinology/Hormones - ATPase - Blebbistatin

Blebbistatin

CAS No. 674289-55-5

Blebbistatin( (±)-Blebbistatin )

Catalog No. M24685 CAS No. 674289-55-5

Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor. It promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 74 In Stock
2MG 42 In Stock
5MG 67 In Stock
10MG 126 In Stock
25MG 215 In Stock
50MG 369 In Stock
100MG 556 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Blebbistatin
  • Note
    Research use only, not for human use.
  • Brief Description
    Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor. It promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing.
  • Description
    Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor. It promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing. Furthermore it preserves cell junctional integrity and barrier function.
  • In Vitro
    ——
  • In Vivo
    Animal Model:New Zealand white rabbits (16-20 weeks; 3-3.5 kg) Dosage:0.05 mL; 20 μM Administration:Intracameral injection; daily; for 6 days Result:Resulted in significant improvement of corneal clarity and corneal edema resolution, implying the restoration of an intact corneal endothelial monolayer.
  • Synonyms
    (±)-Blebbistatin
  • Pathway
    Endocrinology/Hormones
  • Target
    ATPase
  • Recptor
    non-muscle myosin II ATPases
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    674289-55-5
  • Formula Weight
    292.33
  • Molecular Formula
    C18H16N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 23 mg/mL (78.67 mM; Need ultrasonic)
  • SMILES
    Cc(cc1)cc(C(C2(CC3)O)=O)c1N=C2N3c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ho WT, et al. Targeting non-muscle myosin II promotes corneal endothelial migration through regulating lamellipodial dynamics. J Mol Med (Berl). 2019 Sep;97(9):1345-1357.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Fenbufen

    Fenbufen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives class.

  • PK095

    PK095 is a proprietary compound in the guanidine - based F1F0-ATPase inhibitor family.

  • Lycorine

    Lycorine inhibits?protein synthesis and may inhibit?ascorbic acid?biosynthesis, although studies on the latter are controversial and inconclusive.

Sign In Join Free