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Blebbistatin
CAS No. 674289-55-5
Blebbistatin( (±)-Blebbistatin )
Catalog No. M24685 CAS No. 674289-55-5
Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor. It promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 40 | In Stock |
|
| 5MG | 63 | In Stock |
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| 10MG | 120 | In Stock |
|
| 25MG | 203 | In Stock |
|
| 50MG | 357 | In Stock |
|
| 100MG | 538 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBlebbistatin
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NoteResearch use only, not for human use.
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Brief DescriptionBlebbistatin is a selective non-muscle myosin II (NMII) inhibitor. It promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing.
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DescriptionBlebbistatin is a selective non-muscle myosin II (NMII) inhibitor. It promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing. Furthermore it preserves cell junctional integrity and barrier function.
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In Vitro——
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In VivoAnimal Model:New Zealand white rabbits (16-20 weeks; 3-3.5 kg) Dosage:0.05 mL; 20 μM Administration:Intracameral injection; daily; for 6 days Result:Resulted in significant improvement of corneal clarity and corneal edema resolution, implying the restoration of an intact corneal endothelial monolayer.
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Synonyms(±)-Blebbistatin
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PathwayEndocrinology/Hormones
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TargetATPase
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Recptornon-muscle myosin II ATPases
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Research Area——
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Indication——
Chemical Information
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CAS Number674289-55-5
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Formula Weight292.33
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Molecular FormulaC18H16N2O2
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Purity>98% (HPLC)
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SolubilityDMSO : 23 mg/mL (78.67 mM; Need ultrasonic)
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SMILESCc(cc1)cc(C(C2(CC3)O)=O)c1N=C2N3c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ho WT, et al. Targeting non-muscle myosin II promotes corneal endothelial migration through regulating lamellipodial dynamics. J Mol Med (Berl). 2019 Sep;97(9):1345-1357.
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