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Home - Products - MAPK/ERK Signaling - ERK - ERK-IN-4

ERK-IN-4

CAS No. 1049738-54-6

ERK-IN-4( —— )

Catalog No. M34872 CAS No. 1049738-54-6

ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 101 In Stock
2MG 52 In Stock
5MG 85 In Stock
10MG 140 In Stock
25MG 231 In Stock
50MG 334 In Stock
100MG 499 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    ERK-IN-4
  • Note
    Research use only, not for human use.
  • Brief Description
    ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.
  • Description
    ERK-IN-4 is an ERK inhibitor binds preferentially to ERK2 with a Kd of 5 μM. ERK-IN-4 specificity inhibits ERK Rsk-1 and Elk-1 phosphorylation. ERK-IN-4has little effect on ERK protein phosphorylation by its upstream activator MEK1/2.
  • In Vitro
    Cell Proliferation AssayCell Line:HeLa, A549, or SUM-159 cells Concentration:10 μM, 20 μM, 30 μM, 40 μM, 150 μM for A549, or SUM-159 cells; 25 μM, 50 μM, 75 μM for HeLa cells Incubation Time:10 days Result:Completely inhibited cell proliferation.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    ERK
  • Recptor
    ERK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1049738-54-6
  • Formula Weight
    328.814
  • Molecular Formula
    C14H17ClN2O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (76.03 mM; Ultrasonic (<80°C)
  • SMILES
    Cl.O=C1SC(=CC2=CC=C(OCC)C=C2)C(=O)N1CCN
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chad N Hancock, et al. Identification of novel extracellular signal-regulated kinase docking domain inhibitors. J Med Chem. 2005 Jul 14;48(14):4586-95.?
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