Cart
sales@molnova.com
Home - Products - MAPK/ERK Signaling - ERK - BIX02189 (b)

BIX02189 (b)

CAS No. 1094614-85-3

BIX02189 (b)( —— )

Catalog No. M10368 CAS No. 1094614-85-3

BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 84 In Stock
5MG 75 In Stock
10MG 119 In Stock
25MG 221 In Stock
50MG 369 In Stock
100MG 569 In Stock
200MG 806 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    BIX02189 (b)
  • Note
    Research use only, not for human use.
  • Brief Description
    BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays.
  • Description
    BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    ERK
  • Recptor
    ERK5| MEK1| MEK2| MEK5| TGFβR1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1094614-85-3
  • Formula Weight
    440.54
  • Molecular Formula
    C27H28N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 80 mg/mL (181.59 mM); DMSO: 60 mg/mL warmed (136.19 mM)
  • SMILES
    CN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N(C)C)NC2=O)/C4=CC=CC=C4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Tatake RJ, et al. Biochem Biophys Res Commun, 2008, 377(1), 120-125.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Byakangelicol

    Byakangelicol may inhibit P-gp expressed at the BBB even under in vivo conditions.

  • Mogrol

    Mogrol is a biometabolite of mogrosides. Mogrol acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.

  • ERK5-IN-2

    ERK5-IN-2 is an orally active sub-micromolar selective ERK5 inhibitor with IC50s of 0.82 μM 3 μM for ERK5 and ERK5 MEF2D respectively.

Sign In Join Free