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BIX02189 (b)

CAS No. 1094614-85-3

BIX02189 (b)( —— )

Catalog No. M10368 CAS No. 1094614-85-3

BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Size	Price / USD	Stock	Quantity
2MG	43	In Stock
5MG	71	In Stock
10MG	113	In Stock
25MG	210	In Stock
50MG	357	In Stock
100MG	615	In Stock
200MG	857	In Stock
500MG	1251	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

BIX02189 (b)
Note

Research use only, not for human use.
Brief Description

BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays.
Description

BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

MAPK/ERK Signaling
Target

ERK
Recptor

ERK5| MEK1| MEK2| MEK5| TGFβR1
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

1094614-85-3
Formula Weight

440.54
Molecular Formula

C27H28N4O2
Purity

>98% (HPLC)
Solubility

Ethanol: 80 mg/mL (181.59 mM); DMSO: 60 mg/mL warmed (136.19 mM)
SMILES

CN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N(C)C)NC2=O)/C4=CC=CC=C4
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Tatake RJ, et al. Biochem Biophys Res Commun, 2008, 377(1), 120-125.

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