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Home - Products - MAPK/ERK Signaling - ERK - VX-11e

VX-11e

CAS No. 896720-20-0

VX-11e( VX 11e )

Catalog No. M16451 CAS No. 896720-20-0

A potent, selective, and orally bioavailable inhibitor of ERK2 with Ki of <2 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    VX-11e
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, and orally bioavailable inhibitor of ERK2 with Ki of <2 nM.
  • Description
    A potent, selective, and orally bioavailable inhibitor of ERK2 with Ki of <2 nM; shows >200-fold selectivity over GSK3, Aurora A, CDK2, FLT3, etc; significantly inhibits CKAP2 overexpression-induced cell proliferation, migration and invasion in SiHa cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    VX 11e
  • Pathway
    MAPK/ERK Signaling
  • Target
    ERK
  • Recptor
    AuroraA|CDK2|ERK2|FLT3|GSK-3
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    896720-20-0
  • Formula Weight
    500.3523
  • Molecular Formula
    C24H20Cl2FN5O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(C1=CC(C2=NC(NC3=CC=C(F)C=C3Cl)=NC=C2C)=CN1)N[C@@H](C4=CC=CC(Cl)=C4)CO
  • Chemical Name
    1H-Pyrrole-2-carboxamide, 4-[2-[(2-chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Aronov AM, et al. J Med Chem. 2009 Oct 22;52(20):6362-8. 2. Krepler C, et al. Clin Cancer Res. 2016 Apr 1;22(7):1592-602. 3. Guo QS, et al. Sci Rep. 2017 May 18;7(1):2117.
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