Cart
sales@molnova.com
CAFESTOL
CAS No. 469-83-0
CAFESTOL( —— )
Catalog No. M20445 CAS No. 469-83-0
CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 30 | In Stock |
|
| 5MG | 49 | In Stock |
|
| 10MG | 81 | In Stock |
|
| 25MG | 154 | In Stock |
|
| 50MG | 221 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameCAFESTOL
-
NoteResearch use only, not for human use.
-
Brief DescriptionCAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway.
-
DescriptionCAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayMAPK/ERK Signaling
-
TargetERK
-
RecptorERK|COX-2|NF-κB
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number469-83-0
-
Formula Weight316.43
-
Molecular FormulaC20H28O3
-
Purity>98% (HPLC)
-
SolubilityDMSO:5 mg/mL (15.8 mM)
-
SMILES[H][C@]12CC[C@@]34C[C@@H](CC[C@@]3([H])[C@]1(C)CCc1occc21)[C@@](O)(CO)C4
-
Chemical Name(3bS5aS7R8R10aR10bS)-7-(Hydroxymethyl)-10b-methyl-3b4567891010a10b1112-dodecahydro-5a8-methanocyclohepta[56]naphtho[21-b]furan-7-ol
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Shen T Lee J Lee E et al. Cafestol a Coffee-Specific Diterpene Is a Novel Extracellular Signal-Regulated Kinase Inhibitor with AP-1-Targeted Inhibition of Prostaglandin E2 Production in Lipopolysaccharide-Activated Macrophages[J]. Biological & Pharmaceutical Bulletin 2010 33(1):128-132.
molnova catalog
related products
-
ERK5-IN-1
ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).
-
mSIRK
mSIRK (G-Protein βγ Binding Peptide) is a cell-permeable activator of ERK 1/2 with an EC50 of 2.5-5 μM.
-
Ulixertinib hydrochl...
Ulixertinib hydrochloride (Ulixertinib HCl) is an orally available, selective and potent ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosis, and may be used in the study of solid tumors.
