Cart
sales@molnova.com
Home - Products - Apoptosis - Apoptosis - Fluorizoline

Fluorizoline

CAS No. 1362243-70-6

Fluorizoline( —— )

Catalog No. M34601 CAS No. 1362243-70-6

Fluorizoline is a PHB-binding compound with anticancer and antiproliferative activity that induces apoptosis by inducing selective targeting of the BH3 protein NOXA to PHB.Fluorizoline inhibits protein synthesis and has been used in studies of leukemia.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 94 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Fluorizoline
  • Note
    Research use only, not for human use.
  • Brief Description
    Fluorizoline is a PHB-binding compound with anticancer and antiproliferative activity that induces apoptosis by inducing selective targeting of the BH3 protein NOXA to PHB.Fluorizoline inhibits protein synthesis and has been used in studies of leukemia.
  • Description
    Fluorizoline selectively and directly binds to prohibitin 1 (PHB1) and 2 (PHB2), and induces apoptosis. Fluorizoline reduces chronic lymphocytic leukemia (CLL) cell viability through the upregulation of NOXA and BIM. Fluorizoline exerts antitumor action in a p53-independent manner.
  • In Vitro
    Apoptosis Analysis Cell Line:Primary CLL cells Concentration:1.25 to 20 μM Incubation Time:24 hours Result:Strongly reduced cell viability and induced apoptosis in a dose-dependent manner.Western Blot Analysis Cell Line:Primary CLL cells Concentration:5, 10 μM Incubation Time:48 hours Result:Caused an increase of NOXA protein levels.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1362243-70-6
  • Formula Weight
    362.2
  • Molecular Formula
    C15H8Cl2F3NS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (138.05 mM; Ultrasonic )
  • SMILES
    FC1(F)N=C(SC1(F)c1ccc(Cl)cc1)c1ccc(Cl)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ana M Cosialls, et al. The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax. Haematologica. 2017 Sep;102(9):1587-1593.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Pivanex

    Pivanex is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein and enhances apoptosis.

  • Sodium Oxamate

    Sodium Oxamate is an LDH inhibitor.?Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.

  • BTT-3033

    BTT-3033 is an orally active and potent α2β1 (EC50: 130 nM) inhibitor with an affinity for the α2I domain, inhibiting platelet binding to collagen I and cell proliferation.

Sign In Join Free