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Fluorizoline

CAS No. 1362243-70-6

Fluorizoline( —— )

Catalog No. M34601 CAS No. 1362243-70-6

Fluorizoline is a PHB-binding compound with anticancer and antiproliferative activity that induces apoptosis by inducing selective targeting of the BH3 protein NOXA to PHB.Fluorizoline inhibits protein synthesis and has been used in studies of leukemia.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Fluorizoline
  • Note
    Research use only, not for human use.
  • Brief Description
    Fluorizoline is a PHB-binding compound with anticancer and antiproliferative activity that induces apoptosis by inducing selective targeting of the BH3 protein NOXA to PHB.Fluorizoline inhibits protein synthesis and has been used in studies of leukemia.
  • Description
    Fluorizoline selectively and directly binds to prohibitin 1 (PHB1) and 2 (PHB2), and induces apoptosis. Fluorizoline reduces chronic lymphocytic leukemia (CLL) cell viability through the upregulation of NOXA and BIM. Fluorizoline exerts antitumor action in a p53-independent manner.
  • In Vitro
    Apoptosis Analysis Cell Line:Primary CLL cells Concentration:1.25 to 20 μM Incubation Time:24 hours Result:Strongly reduced cell viability and induced apoptosis in a dose-dependent manner.Western Blot Analysis Cell Line:Primary CLL cells Concentration:5, 10 μM Incubation Time:48 hours Result:Caused an increase of NOXA protein levels.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1362243-70-6
  • Formula Weight
    362.2
  • Molecular Formula
    C15H8Cl2F3NS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (138.05 mM; Ultrasonic )
  • SMILES
    FC1(F)N=C(SC1(F)c1ccc(Cl)cc1)c1ccc(Cl)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ana M Cosialls, et al. The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax. Haematologica. 2017 Sep;102(9):1587-1593.?
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