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CCR2 antagonist 5
CAS No. 1228650-83-6
CCR2 antagonist 5( —— )
Catalog No. M34297 CAS No. 1228650-83-6
CCR2 antagonist 5 (JNJ-41443532) is a selective and orally active hCCR2 inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemotaxis IC50=30 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 152 | Get Quote |
|
| 5MG | 235 | Get Quote |
|
| 10MG | 353 | Get Quote |
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| 25MG | 615 | Get Quote |
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| 50MG | 873 | Get Quote |
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| 100MG | 1161 | Get Quote |
|
| 200MG | 1557 | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCCR2 antagonist 5
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NoteResearch use only, not for human use.
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Brief DescriptionCCR2 antagonist 5 (JNJ-41443532) is a selective and orally active hCCR2 inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemotaxis IC50=30 nM).
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DescriptionJNJ-41443532 (CCR2 antagonist 5) is a selective, orally active hCCR2 inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemotaxis IC50=30 nM). JNJ-41443532 displays a Ki of 9.6 μM for mCCR2 binding. JNJ-41443532 can be used in the research of inflammatory disease.
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In Vitro——
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In VivoJNJ-41443532 (compound 8d) dose-dependently inhibits the influx of leukocytes, monocytes/macrophages and T-lymphocytes into the peritoneal cavity with an ED50 of 3 mg/kg p.o. bid in a thioglycollate-induced peritonitis (TG) model.JNJ-41443532 has good CV safety profile. It does not induce dose-dependent or notable effects on most cardiohemodynamic, functional respiratory and electrophysiological parameters up to 10 mg/kg (i.v.) with plasma level at 70 μM in an anesthetized dog.JNJ-41443532 has amendable oral bioavailability in dogs and primates.
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Synonyms——
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PathwayAutophagy
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TargetCCR
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RecptorCCR
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Research Area——
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Indication——
Chemical Information
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CAS Number1228650-83-6
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Formula Weight482.52
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Molecular FormulaC22H25F3N4O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESN(C(CNC(=O)C1=CC(C(F)(F)F)=CC=C1)=O)C2CN([C@@H]3CC[C@@](O)(CC3)C4=CN=CS4)C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhang X, et al. Discovery of a 4-Azetidinyl-1-thiazoyl-cyclohexane CCR2 Antagonist as a Development Candidate. ACS Med Chem Lett. 2012 Oct 8;3(12):1039-44.?
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