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CCR
The cinnamolyl-CoA esters, the precursors of monolignol biosynthesis, are generated by the general phenylpropanoid pathway and then converted into monolignols by two enzymes, cinnamoyl-CoA reductase (CCR) and cinnamyl alcohol dehydrogenase (CAD).Cinnamoyl-CoA reductase (CCR) represents the enzymatic entry step that leads into the monolignol-specific branch of the phenylpropanoid pathway in angiosperms and this also applies to conifer species.Suppression of CCR in angiosperms resulted in lignin reductions of up to 50%, providing evidence for the crucial role of CCR in monolignol biosynthesis. CCR suppression in angiosperms also caused the incorporation of ferulate into the lignin polymer and changes in the metabolite profile.
Autophagy
CCR
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WAY-639418
catalog no : M37702
cas no: 643042-43-7
WAY-639418 has potential anti-inflammatory and anti-HIV activity and can be used to study CCR5-mediated inflammatory and immunomodulatory diseases.
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Plozalizumab
catalog no : M36823
cas no: 1610761-46-0
Plozalizumab (MLN-1202) is a humanized, selective, and potent anti-CCR2 antibody with antitumor activity, used in the study of malignant melanoma.
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Leronlimab
catalog no : M36806
cas no: 674782-26-4
Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody with both anti-HIV and anti-tumor activity, inhibiting CCR-mediated HIV-1 virus and cancer cell metastasis in mouse tumor models. Leronlimab can be used to study HIV, non-alcoholic steatohepatitis (NASH), and breast cancer.
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CCR4 antagonist 3-1
catalog no : M35402
cas no: 1957-01-3
CCR4 antagonist 3-1 is a less active chemokine receptor 4 (CCR4) antagonist that inhibits [125I]TARC (thymus and activation-regulated chemokine) with an IC50 value of 1.7 μM.
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CCR6 antagonist 1
catalog no : M35340
cas no: 588674-64-0
CCR6 antagonist 1, a chemical compound acting as a CCR6 antagonist, effectively inhibits the CCL20/CCR6 axis. Its utility lies in research focused on autoimmune-mediated inflammatory diseases, including inflammatory bowel diseases (IBDs).