INCB 3284( —— )

Catalog No. M32966 CAS No. 887401-92-5

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HNMR

HPLC

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Product Name

INCB 3284
Note

Research use only, not for human use.
Brief Description

INCB 3284 is an orally available, selective and high affinity chemokine receptor 2 (CCR2) antagonist that inhibits monocyte chemotactic protein 1 from interacting with hCCR2.
Description

INCB 3284 is a potent, selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2, with an IC50 of 3.7 nM. INCB 3284 can be used in the research of acute liver failure.
In Vitro

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In Vivo

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Synonyms

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Pathway

Autophagy
Target

CCR
Recptor

CCR
Research Area

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Indication

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CAS Number

887401-92-5
Formula Weight

520.54
Molecular Formula

C26H31F3N4O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : ≥ 83.3 mg/mL (160.03 mM) H2O : < 0.1 mg/mL (insoluble)
SMILES

COc1ccc(cn1)[C@@]1(O)CC[C@@H](CC1)N1CC[C@H](C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F
Chemical Name

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1. Xue CB, et al. Discovery of INCB3284, a Potent, Selective, and Orally Bioavailable hCCR2 Antagonist. ACS Med Chem Lett. 2011 Mar 31;2(6):450-4.?

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