Cart
sales@molnova.com
4-PPBP maleate
CAS No. 201216-39-9
4-PPBP maleate( —— )
Catalog No. M33824 CAS No. 201216-39-9
4-PPBP maleate is a potent σ1 receptor (ligand) agonist and a selective, non-competitive NR1a/2B NMDA receptor antagonist in the context of Xenopus oocytes expression, with neuroprotective properties.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 34 | In Stock |
|
| 5MG | 29 | In Stock |
|
| 10MG | 46 | In Stock |
|
| 25MG | 91 | In Stock |
|
| 50MG | 144 | In Stock |
|
| 100MG | 214 | In Stock |
|
| 200MG | 303 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product Name4-PPBP maleate
-
NoteResearch use only, not for human use.
-
Brief Description4-PPBP maleate is a potent σ1 receptor (ligand) agonist and a selective, non-competitive NR1a/2B NMDA receptor antagonist in the context of Xenopus oocytes expression, with neuroprotective properties.
-
Description4-PPBP maleate is a potent σ 1 receptor ligand and agonist. 4-PPBP maleate is a non-competitive, selective NR1a/2B NMDA receptors (expressed in Xenopus oocytes) antagonist. 4-PPBP maleate provides neuroprotection.
-
In Vitro4-PPBP maleate elicits ERK1/2 phosphorylation in primary neurons.
-
In Vivo4-PPBP maleate (1 μmol/kg; i.v.) decreases brain injury after transient focal ischemia in rats.Animal Model:Male rats weighing 300 to 385 g (Transient focal ischemia model)Dosage:1 μmol/kg Administration:Per hour by continuous intravenous infusion starting 1 hour after the initiation of ischemia and continuing through 22 hours of reperfusion.Result:Decreased brain injury after transient focal ischemia in rats.
-
Synonyms——
-
PathwayAutophagy
-
TargetSigma receptor
-
RecptorSigma receptor | NMDAR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number201216-39-9
-
Formula Weight409.52
-
Molecular FormulaC25H31NO4
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 250 mg/mL (610.47 mM; Ultrasonic )
-
SMILESC(=C\C(O)=O)\C(O)=O.C(CCCC1=CC=CC=C1)N2CCC(CC2)C3=CC=CC=C3
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Whittemore ER, et al. Antagonism of N-methyl-D-aspartate receptors by sigma site ligands: potency, subtype-selectivity and mechanisms of inhibition. J Pharmacol Exp Ther. 1997;282(1):326-338.?
molnova catalog
related products
-
S1R agonist 2
S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.
-
Glycerol phenylbutyr...
Glycerol phenylbutyrate (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).Glycerol phenylbutyrate may have therapeutic potential in additional conditions such as chronic hepatic encephalopathy or other inherited metabolic disorders. Glycerol phenylbutyrate also has the potential for the treatment of hyperammonemia.
-
A-205804
A-205804 is a specific and effective inhibitor of E-selectin( IC50=20 nM ) and ICAM-1(IC50=25 nM) expression.
