BD1063

Research use only, not for human use.

BD1063 is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).

BD1063 is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).

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BD1063 dose-dependently reduces ethanol self-administration in sP rats (3.3-11 mg/kg) and withdrawn, dependent Wistar rats (4-11 mg/kg) at doses that does not modify mean ethanol self-administration in non-dependent Wistar controls. BD1063also reduces the breakpoints of sP rats to work for ethanol under a progressive-ratio reinforcement schedule. BD1063dose-dependently reduces binge-like eating and the regularity of food responding, and blocks the increased eating rate in Palatable rats. In the light/dark conflict test, BD1063antagonizes the increased time spent in the aversive compartment and the increased intake of the palatable diet, without affecting motor activity. The administration of BD106330 minutes before each paclitaxel dose prevents the development of cold and mechanical allodynia in WT mice. Moreover, the acute administration of BD1063 dose dependently reverses both types of paclitaxel-induced allodynia.

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Autophagy

Sigma receptor

σ1

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206996-13-6

346.12

C13H20Cl4N2

>98% (HPLC)

H2O:50 mg/mL (144.46 mM)

CN1CCN(CCc2ccc(Cl)c(Cl)c2)CC1.Cl.Cl

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(-20℃)

With Ice Pack

≥ 2 years