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UNC-0642
CAS No. 1481677-78-4
UNC-0642( AHU-377 )
Catalog No. M17319 CAS No. 1481677-78-4
UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 91 | In Stock |
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| 2MG | 46 | In Stock |
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| 5MG | 75 | In Stock |
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| 10MG | 126 | In Stock |
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| 25MG | 231 | In Stock |
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| 50MG | 369 | In Stock |
|
| 100MG | 555 | In Stock |
|
| 200MG | 807 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameUNC-0642
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NoteResearch use only, not for human use.
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Brief DescriptionUNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).
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DescriptionUNC0642 is a potent, selective inhibitor of G9a/GLP with improved PK properties. UNC0642 exhibits an in vitro IC50 <15 nM with selectivity > 100-fold over 13 other HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. In cells, UNC0642 results in a potent reduction of H3K9me2 in MDA MB231 cells with IC50 = 106 nM.
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In Vitro——
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In Vivo——
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SynonymsAHU-377
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PathwayAutophagy
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TargetSigma receptor
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RecptorG9a/GLP
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number1481677-78-4
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Formula Weight546.69
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Molecular FormulaC29H44F2N6O2
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Purity>98% (HPLC)
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SolubilityDMSO : 295 mg/mL. 539.60 mM;
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SMILESCC(N1CCC(Nc2c3cc(OC)c(OCCCN4CCCC4)cc3nc(N3CCC(F)(F)CC3)n2)CC1)C
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Chemical Name2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Liu F, et al. Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. J Med Chem. 2013 Nov 14;56(21):8931-42. doi: 10.1021/jm401480r. Epub 2013 Oct 31.
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