Sigma-1 receptor antagonist 1( —— )

Catalog No. M26443 CAS No. 1639220-19-1

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Product Name

Sigma-1 receptor antagonist 1
Note

Research use only, not for human use.
Brief Description

Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor.
Description

Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor. Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity and can be used in the treatment of neuropathic pain studies.(In Vitro):Sigma 1 receptor antagonist 1 exhibits a high binding affinity to σ1R receptor with Ki of 1.06 nM and good σ-1/2 selectivity (1344-fold).(In Vivo):In mice formalin model and rats CCI models of neuropathic pain, Sigma 1 receptor antagonist 1 exerts dose-dependent antinociceptive effects.
In Vitro

Sigma?1 receptor antagonist 1 exhibits a high binding affinity to σ1R receptor (Ki = 1.06 nM) and good σ-1/2 selectivity (1344-fold).
In Vivo

Sigma1 receptor antagonist 1 exerts dose-dependent antinociceptive effects in mice formalin model and rats CCI models of neuropathic pain.
Synonyms

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Pathway

Autophagy
Target

Sigma receptor
Recptor

TLR7| TLR8
Research Area

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Indication

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1.Martha A. MILLER, et al. Vaccine compositions and methods of use to treat neonatal subjects.

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